{"id":"W2917942725","doi":"10.1002/pbc.27676","title":"Phase I dose‐finding study for melatonin in pediatric oncology patients with relapsed solid tumors","year":2019,"lang":"en","type":"article","venue":"Pediatric Blood & Cancer","topic":"Circadian rhythm and melatonin","field":"Neuroscience","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine; Alberta Children's Hospital; BC Children's Hospital; University of Toronto; SickKids Foundation; Hospital for Sick Children; Children's Hospital of Eastern Ontario","funders":"Kids With Cancer Society; Childhood Cancer Canada; C17 Council","keywords":"Melatonin; Medicine; Tolerability; Maximum tolerated dose; Adverse effect; Anorexia; Concomitant; Pediatric cancer; Population; Internal medicine; Chemotherapy; Cancer; Oncology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001434746,0.001390784,0.001736001,0.0003674177,0.0005549124,0.0006319275,0.0009146137,0.0008148433,0.002667434],"category_scores_gemma":[0.0007277084,0.0004241125,0.001079884,0.00051758,0.0008718565,0.0005643664,0.0002789927,0.003051232,0.000581201],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009217475,"about_ca_system_score_gemma":0.001969097,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007577279,"about_ca_topic_score_gemma":0.002060483,"domain_scores_codex":[0.999604,0.0002081856,0.00002387518,0.000054172,0.00004288186,0.00006690905],"domain_scores_gemma":[0.9991597,0.0001509041,0.0002133818,0.00008992731,0.00007785418,0.0003082874],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.4609382,0.1459126,0.02775083,0.002082948,0.002084333,0.001017582,0.001048926,0.005948219,0.1834334,0.0005801567,0.007697341,0.1615055],"study_design_scores_gemma":[0.2283279,0.7399927,0.01444796,0.00005375506,0.0003772086,0.0007348571,0.00008677551,0.0009299737,0.01064521,0.0001854446,0.004195319,0.00002285736],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9908903,0.002124703,0.001275058,0.0004965332,0.00009710742,0.003421903,0.0006635772,0.0001077799,0.0009230031],"genre_scores_gemma":[0.9845808,0.002352722,0.005509585,0.0006644136,0.0001435096,0.004324508,0.001252745,0.00004653927,0.001125141],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002667434,"threshold_uncertainty_score":0.008923411,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02139210085732214,"score_gpt":0.3111728121241032,"score_spread":0.2897807112667811,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}