{"id":"W2918027232","doi":"10.3390/genes10030183","title":"Progression of Cystic Fibrosis Lung Disease from Childhood to Adulthood: Neutrophils, Neutrophil Extracellular Trap (NET) Formation, and NET Degradation","year":2019,"lang":"en","type":"review","venue":"Genes","topic":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","field":"Immunology and Microbiology","cited_by":114,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; University of Toronto; Hospital for Sick Children","funders":"Canadian Institutes of Health Research; Mitacs; Cystic Fibrosis Canada","keywords":"Neutrophil extracellular traps; Cystic fibrosis; Immunology; Mucus; Lung; Inflammation; Cystic fibrosis transmembrane conductance regulator; Medicine; Biology; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001638716,0.0003093908,0.0002176498,0.000510079,0.0002478416,0.0004530542,0.0001298018,0.0005247061,0.0009010771],"category_scores_gemma":[0.0004606149,0.0001279362,0.0001694523,0.0003626824,0.0001925166,0.000459568,0.0003759371,0.0005704008,0.000208576],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004741878,"about_ca_system_score_gemma":0.000499193,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005514905,"about_ca_topic_score_gemma":0.004953435,"domain_scores_codex":[0.9998684,0.00001784115,0.00001341751,0.00003034485,0.00003666709,0.00003318895],"domain_scores_gemma":[0.9996861,0.00002503139,0.000169518,0.000006964196,0.00004255149,0.00006990256],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000916602,0.0001662012,0.8304814,0.0005310484,0.00008098208,0.008432832,0.0009449296,0.0004469224,0.03973249,0.0012462,0.00500233,0.1120181],"study_design_scores_gemma":[0.00001295604,0.0002765968,0.9654192,0.0002046121,0.00006169914,0.01923586,0.0004641041,0.0004198455,0.004288288,0.0004006553,0.009197609,0.00001850116],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.9244339,0.06469986,0.001873223,0.001788213,0.00008883217,0.00005403643,0.001648838,0.0001788336,0.005234308],"genre_scores_gemma":[0.9755087,0.02065063,0.001406456,0.000203629,0.00005220664,0.00002648344,0.0007437144,0.000008240243,0.001399853],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.005514905,"threshold_uncertainty_score":0.01096565,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02103033884428994,"score_gpt":0.2731787409728529,"score_spread":0.252148402128563,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}