{"id":"W2918113141","doi":"10.1038/s41416-019-0393-x","title":"Genome-wide association study of germline variants and breast cancer-specific mortality","year":2019,"lang":"en","type":"review","venue":"British Journal of Cancer","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":73,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; BC Cancer Agency; Centre hospitalier universitaire de Québec; Sinai Health System; University of British Columbia; Centre hospitalier de l'Université Laval; Vancouver General Hospital; Mount Sinai Hospital; Lunenfeld-Tanenbaum Research Institute; Public Health Ontario; University Health Network; University of Toronto","funders":"Servicio Gallego de Salud; Programme Grants for Applied Research; Biotieteiden ja Ympäristön Tutkimuksen Toimikunta; Instituto de Salud Carlos III; Medical Research Council; Imperial Experimental Cancer Medicine Centre; National Institutes of Health; Hellenic Health Foundation; Freistaat Sachsen; Deutschen Konsortium für Translationale Krebsforschung; Xunta de Galicia; Rheinische Friedrich-Wilhelms-Universität Bonn; Mutuelle Générale de l'Education Nationale; Institut Gustave-Roussy; Ministero dello Sviluppo Economico; Centers for Disease Control and Prevention; Institut National Du Cancer; Canadian Institutes of Health Research; Sigrid Juséliuksen Säätiö; National Health and Medical Research Council; Oulun Yliopisto; Deutsche Krebshilfe; KWF Kankerbestrijding; Vetenskapsrådet; Stockholms Läns Landsting; Ligue Contre le Cancer; Kuopion Yliopistollinen Sairaala; Karolinska Institutet; Ovarian Cancer Research Fund; Bundesministerium für Bildung und Forschung; Ministerio de Economía y Competitividad; Air Force Materiel Command; European Regional Development Fund; King's College London; Academy of Finland; Russian Foundation for Basic Research; University of Crete; Institut National de la Santé et de la Recherche Médicale; Cancer Australia; Agence Nationale de la Recherche; National Institute on Aging; Robert Bosch Stiftung; University of Westminster; European Commission; Cancerfonden; National Cancer Institute; Breast Cancer Now; Cancer Institute NSW; Fondation de France; NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research; Breast Cancer Campaign; Eberhard Karls Universität Tübingen; Fondation du cancer du sein du Québec; National Breast Cancer Foundation; Agence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail; Swedish Cancer Foundation; Agency for Science, Technology and Research; Lon V. Smith Foundation; Ministère du Développement Économique, de l’Innovation et de l’Exportation; Gentofte Hospital; Deutsche Gesetzliche Unfallversicherung; University of California, Irvine; Kreftforeningen; David F. and Margaret T. Grohne Family Foundation; Cancer Research UK; U.S. Department of Defense; National Heart, Lung, and Blood Institute; Itä-Suomen Yliopisto; Genome Canada; Sundhed og Sygdom, Det Frie Forskningsråd; Centre International de Recherche sur le Cancer; Deutsches Krebsforschungszentrum; World Cancer Research Fund; Helsingin ja Uudenmaan Sairaanhoitopiiri; Susan G. Komen for the Cure; Stavros Niarchos Foundation; University of Southern California; Associazione Italiana per la Ricerca sul Cancro; Beckman Research Institute, City of Hope; Cancer Council Victoria; California Department of Public Health; Ministerio de Sanidad, Servicios Sociales e Igualdad; University of Cambridge; Government of Canada; U.S. Department of Health and Human Services; American Cancer Society; Breast Cancer Research Foundation; National Institute for Health and Care Research; Norges Forskningsråd; Division of Cancer Prevention, National Cancer Institute","keywords":"Breast cancer; Hazard ratio; Germline; Oncology; Genome-wide association study; Germline mutation; Cancer; Biology; Confidence interval; Internal medicine; Disease; Genetics; Medicine; Gene; Single-nucleotide polymorphism; Mutation; Genotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00555527,0.001357328,0.001908434,0.00237761,0.0005425363,0.001490907,0.0008986561,0.001321445,0.001429494],"category_scores_gemma":[0.008145412,0.0007119882,0.01016183,0.003297021,0.0004787696,0.000482088,0.0009112343,0.00116927,0.0001947593],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004519851,"about_ca_system_score_gemma":0.0005901592,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004470438,"about_ca_topic_score_gemma":0.00596437,"domain_scores_codex":[0.996187,0.001752931,0.0003471758,0.001112231,0.0003664146,0.000234341],"domain_scores_gemma":[0.9960005,0.002271088,0.0006607064,0.0006272132,0.0002662935,0.000174164],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004551921,0.00008025677,0.6582117,0.002287897,0.3080642,0.0008226582,0.0001442118,0.003737608,0.003515489,0.0004309755,0.001219156,0.0169339],"study_design_scores_gemma":[0.001390176,0.001151738,0.5673928,0.0009533286,0.4113546,0.001406793,0.0002120635,0.00743439,0.00192082,0.002196491,0.0045007,0.00008615264],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.8207625,0.1654974,0.007043415,0.001177118,0.0004818486,0.00006511107,0.003506784,0.0002365716,0.001229274],"genre_scores_gemma":[0.9891115,0.008183014,0.001152651,0.0002371411,0.0001376586,0.00003801574,0.0008865952,0.00002922653,0.000224318],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.00555527,"threshold_uncertainty_score":0.02937943,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03285698338437489,"score_gpt":0.3435886946455268,"score_spread":0.310731711261152,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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