{"id":"W2918180482","doi":"10.1111/hiv.12716","title":"Two‐drug <i>vs</i>. three‐drug combinations for <scp>HIV</scp>‐1: Do we have enough data to make the switch?","year":2019,"lang":"en","type":"review","venue":"HIV Medicine","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":82,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"Cilag; ViiV Healthcare; Gilead Sciences; Pfizer; Bristol-Myers Squibb","keywords":"Medicine; Drug; Regimen; Adverse effect; Viral load; Pharmacology; Drug resistance; Pill; Combination therapy; HIV drug resistance; Human immunodeficiency virus (HIV); Intensive care medicine; Antiretroviral therapy; Immunology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001779606,0.001263632,0.003913556,0.00061156,0.0004034926,0.00007049936,0.001754557,0.0002621562,0.0002025145],"category_scores_gemma":[0.001191331,0.0007056443,0.0004977506,0.0008771805,0.0002552864,0.0001254244,0.0007501763,0.00093538,0.001964336],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003715964,"about_ca_system_score_gemma":0.001090851,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005064734,"about_ca_topic_score_gemma":0.0002533206,"domain_scores_codex":[0.9942505,0.0002000266,0.001607763,0.00159866,0.001313783,0.001029279],"domain_scores_gemma":[0.991345,0.003216581,0.0006848811,0.003800064,0.0003521812,0.0006013164],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002194911,0.0003571083,0.000100857,0.007536588,0.001032153,0.00008033938,0.001812989,5.083888e-7,4.777243e-7,0.001466274,0.7785745,0.2090163],"study_design_scores_gemma":[0.006739711,0.0001609725,0.00002128295,0.02774957,0.007775715,0.0001729369,0.0007221167,0.0000589589,0.000002530637,0.0001967024,0.9560817,0.0003177547],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000006909327,0.9141398,0.0005594407,0.06401866,0.001323336,0.009413911,0.001131191,0.0001793495,0.009227381],"genre_scores_gemma":[0.00001898092,0.781199,0.001462172,0.001428429,0.001504164,0.001091632,0.01031681,0.0002205398,0.2027583],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.2086985,"threshold_uncertainty_score":0.9995395,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1112295242288524,"score_gpt":0.3698249872706382,"score_spread":0.2585954630417858,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}