{"id":"W2918271856","doi":"10.1038/s41590-019-0334-0","title":"SLAM receptors foster iNKT cell development by reducing TCR signal strength after positive selection","year":2019,"lang":"en","type":"article","venue":"Nature Immunology","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":76,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Université du Québec; University of Toronto; Université de Montréal; Montreal Clinical Research Institute","funders":"Nature","keywords":"T-cell receptor; FYN; Cell biology; Receptor; Biology; CD8; Downregulation and upregulation; CD1D; Signal transduction; Immunology; T cell; Antigen; Immune system; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0001753654,0.0003349967,0.000341735,0.0002595122,0.0002055184,0.00002819324,0.0002005041,0.001430331,0.01504572],"category_scores_gemma":[0.00002775782,0.000313115,0.0001186198,0.0002205495,0.00009154066,0.0002591237,0.0001118553,0.002074181,0.006113375],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002973171,"about_ca_system_score_gemma":0.0001111708,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003794217,"about_ca_topic_score_gemma":0.000008916738,"domain_scores_codex":[0.9980879,0.0003137685,0.0004387454,0.0005610599,0.00005884783,0.0005396151],"domain_scores_gemma":[0.9991902,0.0001267663,0.0002210872,0.0002437541,0.0001989463,0.00001926052],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001708577,0.0002178951,0.001047072,0.00001289038,0.0003117199,0.000001501263,0.0009635865,0.000001927729,0.9278796,0.00003341387,0.05920288,0.0086189],"study_design_scores_gemma":[0.0009951069,0.0003559364,0.002365596,0.00003428019,0.0000217006,0.00006273449,0.0002687938,0.000002071831,0.6019313,0.000004859141,0.3937141,0.0002434481],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9674793,0.008530118,0.000119852,0.0002866145,0.01327831,0.0004414115,0.000007723676,0.0001626059,0.009694071],"genre_scores_gemma":[0.9202672,0.00006277388,0.0001369397,0.0007742241,0.00005057246,0.00004789952,0.0005927771,0.00003704937,0.07803055],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3345113,"threshold_uncertainty_score":0.9999321,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.002287333849049027,"score_gpt":0.1945060231400454,"score_spread":0.1922186892909964,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}