{"id":"W2918325303","doi":"10.21769/bioprotoc.3188","title":"Differentiation of Human Induced Pluripotent Stem Cells (iPSCs) into an Effective Model of Forebrain Neural Progenitor Cells and Mature Neurons","year":2019,"lang":"en","type":"article","venue":"BIO-PROTOCOL","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Douglas Mental Health University Institute","funders":"Fonds de Recherche du Québec - Santé; Consejo Nacional de Ciencia y Tecnología; Canada Research Chairs","keywords":"Forebrain; Induced pluripotent stem cell; Neuroscience; Biology; Neural stem cell; Progenitor cell; Cell biology; Stem cell; Embryonic stem cell; Central nervous system; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001925972,0.0002584791,0.0003047097,0.0001097464,0.00006575233,0.00002742331,0.0003104782,0.0002818813,0.00001099077],"category_scores_gemma":[0.000007039133,0.0002236188,0.0001190118,0.0001015481,0.00009137827,0.00001698075,0.0002835262,0.000176047,0.000003995557],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002489048,"about_ca_system_score_gemma":0.00005564815,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000335697,"about_ca_topic_score_gemma":0.00001938972,"domain_scores_codex":[0.9982013,0.0002379961,0.0003841563,0.0005484314,0.0003279386,0.0003002288],"domain_scores_gemma":[0.9988417,0.00001605074,0.0002698847,0.0005603068,0.000174479,0.0001375858],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004352993,0.0002499284,0.002067856,0.0007594578,0.00004187808,8.547228e-7,0.0001163852,0.000179516,0.9943678,0.00002172583,0.00005991666,0.00169936],"study_design_scores_gemma":[0.001935223,0.002073339,0.002582692,0.00003778262,0.00001528815,0.000001162702,0.0000614418,0.009562571,0.9833788,0.00005584054,0.00008808377,0.0002078093],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7866924,0.000002977451,0.00008584266,0.00001231054,0.00003822924,0.2130708,0.00004163555,0.00001038027,0.00004532965],"genre_scores_gemma":[0.8480579,4.924887e-7,0.0001692812,0.00001768835,0.00005382437,0.1514561,0.00003056665,0.00003706692,0.0001770143],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06161473,"threshold_uncertainty_score":0.911891,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01795633831281876,"score_gpt":0.2946196285685252,"score_spread":0.2766632902557065,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}