{"id":"W2918325303","doi":"10.21769/bioprotoc.3188","title":"Differentiation of Human Induced Pluripotent Stem Cells (iPSCs) into an Effective Model of Forebrain Neural Progenitor Cells and Mature Neurons","year":2019,"lang":"en","type":"article","venue":"BIO-PROTOCOL","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Douglas Mental Health University Institute","funders":"Fonds de Recherche du Québec - Santé; Consejo Nacional de Ciencia y Tecnología; Canada Research Chairs","keywords":"Forebrain; Induced pluripotent stem cell; Neuroscience; Biology; Neural stem cell; Progenitor cell; Cell biology; Stem cell; Embryonic stem cell; Central nervous system; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004956293,0.0005417094,0.0002507982,0.0005907807,0.0003315121,0.000337744,0.0003810239,0.0004652736,0.002671256],"category_scores_gemma":[0.0002025079,0.0002313319,0.0003675557,0.0003243963,0.0002172281,0.0003066465,0.0003425587,0.001172715,0.00130161],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002586019,"about_ca_system_score_gemma":0.0007385992,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007098943,"about_ca_topic_score_gemma":0.001626795,"domain_scores_codex":[0.9997351,0.00003098671,0.00004433852,0.00003974221,0.0001283532,0.00002155145],"domain_scores_gemma":[0.9998933,0.00001659808,0.00001375439,0.00002463822,0.00003237545,0.00001933306],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005346915,0.00005081895,0.0001218808,0.0001387337,0.00001037531,0.0001575024,0.00004140675,0.0002644542,0.9861373,0.002744492,0.001185513,0.009094065],"study_design_scores_gemma":[0.00003583377,0.0002212794,0.001146615,0.00006668409,0.00005608518,0.0006165492,0.00002666523,0.001545365,0.9449483,0.0009229642,0.05040085,0.00001284527],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.3681368,0.01180816,0.5202705,0.001270583,0.002442147,0.005615877,0.01723892,0.00239745,0.0708197],"genre_scores_gemma":[0.5780676,0.01735543,0.2870005,0.0009848656,0.0002409621,0.005820282,0.02495284,0.0004876996,0.08508979],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.002671256,"threshold_uncertainty_score":0.008936167,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01795633831281876,"score_gpt":0.2946196285685252,"score_spread":0.2766632902557065,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}