{"id":"W2918542982","doi":"10.1182/blood-2018-09-876292","title":"Ibrutinib therapy downregulates AID enzyme and proliferative fractions in chronic lymphocytic leukemia","year":2019,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Clinical Research Institute","funders":"National Cancer Institute; CLL Global Research Foundation","keywords":"Ibrutinib; Idelalisib; Chronic lymphocytic leukemia; Somatic hypermutation; IGHV@; Cytidine deaminase; Activation-induced (cytidine) deaminase; Cancer research; Bruton's tyrosine kinase; Venetoclax; breakpoint cluster region; Leukemia; Immunology; Medicine; Oncology; Biology; Tyrosine kinase; B cell; Internal medicine; Antibody; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001290492,0.0001485555,0.0002274572,0.0002971409,0.0001284071,0.0003336733,0.00007228983,0.0001171757,0.0007421835],"category_scores_gemma":[0.0002303496,0.00006403899,0.00007594618,0.000201148,0.0001319325,0.00009061756,0.00009770618,0.0002643994,0.000146212],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000320109,"about_ca_system_score_gemma":0.000164507,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001046471,"about_ca_topic_score_gemma":0.001586913,"domain_scores_codex":[0.999917,0.00001414063,0.000005945306,0.00001211289,0.00001863678,0.00003212972],"domain_scores_gemma":[0.9999199,0.00001820874,0.00002443268,0.00000739303,0.000007438625,0.00002269956],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003359255,0.0003383991,0.01932929,0.00005551619,0.00002558643,0.0001594345,0.0001233786,0.0002639346,0.9464108,0.00008195299,0.0002884319,0.02956397],"study_design_scores_gemma":[0.0003083836,0.006154942,0.5614327,0.00002333802,0.0001340106,0.001143344,0.000246734,0.00171753,0.4180318,0.0001497933,0.01064012,0.00001726573],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978902,0.001354117,0.0001263827,0.00002210461,0.000004900819,0.000005330438,0.0001110132,0.00001846946,0.0004674871],"genre_scores_gemma":[0.9986474,0.0004012733,0.0001251409,0.00002581774,0.000008111526,0.0000120742,0.0002615786,0.00000419255,0.0005145551],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001046471,"threshold_uncertainty_score":0.002482891,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0156079771638856,"score_gpt":0.2860090554580569,"score_spread":0.2704010782941713,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}