{"id":"W2918786363","doi":"10.1002/mrd.23137","title":"Ectopic expression of DNA methyltransferases DNMT3A2 and DNMT3L leads to aberrant hypermethylation and postnatal lethality in mice","year":2019,"lang":"en","type":"article","venue":"Molecular Reproduction and Development","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; Japan Society for the Promotion of Science; RIKEN; Tokyo University of Agriculture","keywords":"Biology; DNA methylation; Genomic imprinting; Methylation; Methyltransferase; Somatic cell; DNA methyltransferase; Transgene; Epigenetics; Molecular biology; Gene; RNA-Directed DNA Methylation; Genetics; Epigenetics of physical exercise; Gene expression","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003301531,0.0007188685,0.0004578234,0.0009578322,0.0002671428,0.00043276,0.0005096513,0.0006696134,0.002257061],"category_scores_gemma":[0.0002573549,0.0006405666,0.000466566,0.0002985604,0.000618652,0.0002406027,0.0004876374,0.001230204,0.001040369],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004501928,"about_ca_system_score_gemma":0.0004112578,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009098662,"about_ca_topic_score_gemma":0.001171999,"domain_scores_codex":[0.9995485,0.00005849612,0.00005181169,0.0001197573,0.0001392298,0.00008216745],"domain_scores_gemma":[0.9994346,0.000093043,0.0002170171,0.00005207267,0.00002263465,0.0001804479],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009907832,0.00002216474,0.0001883308,0.00001914306,0.00001112206,0.0001452184,0.00002450518,0.0001034617,0.9983314,0.0001997398,0.00004838824,0.0008074422],"study_design_scores_gemma":[0.00007764643,0.00035889,0.005324165,0.00002281497,0.00004800727,0.001009703,0.00004336694,0.002147173,0.9872754,0.0002365743,0.003443227,0.00001306313],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9790853,0.001495836,0.01356687,0.0002404738,0.00006054237,0.00005971418,0.002136698,0.0009495526,0.002404987],"genre_scores_gemma":[0.9772279,0.001557887,0.007463621,0.0001511088,0.00002744185,0.0001476407,0.001919123,0.0004518306,0.01105347],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002257061,"threshold_uncertainty_score":0.007550597,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01032831937045057,"score_gpt":0.2470449823110633,"score_spread":0.2367166629406127,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}