{"id":"W2918786363","doi":"10.1002/mrd.23137","title":"Ectopic expression of DNA methyltransferases DNMT3A2 and DNMT3L leads to aberrant hypermethylation and postnatal lethality in mice","year":2019,"lang":"en","type":"article","venue":"Molecular Reproduction and Development","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; Japan Society for the Promotion of Science; RIKEN; Tokyo University of Agriculture","keywords":"Biology; DNA methylation; Genomic imprinting; Methylation; Methyltransferase; Somatic cell; DNA methyltransferase; Transgene; Epigenetics; Molecular biology; Gene; RNA-Directed DNA Methylation; Genetics; Epigenetics of physical exercise; Gene expression","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004350481,0.0001247825,0.0001562819,0.00009535035,0.00004025911,0.00001467583,0.00003495514,0.00009014351,0.000005563747],"category_scores_gemma":[0.00007052524,0.0001221436,0.00001642432,0.00008205999,0.00003411897,0.000009726956,0.00007457638,0.00005451247,0.000001143383],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001070357,"about_ca_system_score_gemma":0.00003490076,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003344651,"about_ca_topic_score_gemma":0.0000167205,"domain_scores_codex":[0.9988815,0.00007899824,0.0002561417,0.0005267299,0.0001251015,0.000131497],"domain_scores_gemma":[0.9996256,0.000009020811,0.00005049262,0.0001920618,0.00005985268,0.00006303352],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006847203,0.00002887018,0.02145067,0.00005780359,0.000007992004,0.000001271504,0.0003266085,0.00008248754,0.9669038,0.00002357296,0.000002372412,0.01104608],"study_design_scores_gemma":[0.000400206,0.0001087598,0.1472383,0.00002465955,0.000004310205,0.000007407819,0.00006480146,0.000006697316,0.8503625,0.00003408447,0.00161863,0.0001297231],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938342,0.002857084,0.002629814,0.0001730085,0.00008392284,0.0003204208,0.000002325401,0.000005374634,0.00009384813],"genre_scores_gemma":[0.9950193,0.0003246351,0.00444375,0.00005268944,0.00001981923,0.00001264321,0.00003925303,0.00001113679,0.0000767637],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1257876,"threshold_uncertainty_score":0.4980873,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01032831937045057,"score_gpt":0.2470449823110633,"score_spread":0.2367166629406127,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}