{"id":"W2918792618","doi":"10.3390/ijms20051116","title":"Regulatory Effect of DNA Topoisomerase I on T3SS Activity, Antibiotic Susceptibility and Quorum- Sensing-Independent Pyocyanin Synthesis in Pseudomonas aeruginosa","year":2019,"lang":"en","type":"article","venue":"International Journal of Molecular Sciences","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Natural Science Foundation of Shaanxi Provincial Department of Education; Changjiang Scholar Program of Chinese Ministry of Education; Natural Sciences and Engineering Research Council of Canada; Natural Science Foundation of Shaanxi Province; National Natural Science Foundation of China","keywords":"Pyocyanin; Pseudomonas aeruginosa; Quorum sensing; Mutant; DNA supercoil; Topoisomerase; Biology; Biofilm; DNA; Microbiology; Gene; DNA replication; Bacteria; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001382014,0.0004992121,0.000332858,0.0001814105,0.0001528383,0.0003074208,0.0001734001,0.0003513029,0.0005082519],"category_scores_gemma":[0.0002559108,0.0001570114,0.0002764224,0.0001329199,0.0003254396,0.0001580709,0.0002206377,0.0004326096,0.000181578],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003570881,"about_ca_system_score_gemma":0.0003596924,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001904004,"about_ca_topic_score_gemma":0.0009628347,"domain_scores_codex":[0.9998115,0.00004115409,0.00001854849,0.00003561151,0.00005719513,0.00003602806],"domain_scores_gemma":[0.9998301,0.00004461029,0.00004575682,0.00001835082,0.00001712015,0.00004397345],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006810575,0.00001103855,0.0001221463,0.0000133485,0.000001838094,0.00003192104,0.000007210067,0.00002442731,0.999374,0.00001625104,0.000005631385,0.0003241979],"study_design_scores_gemma":[0.00001728923,0.0002727175,0.01005674,0.000005414229,0.00001603308,0.000233287,0.00004196625,0.001310865,0.9875272,0.0000620098,0.0004456215,0.00001095595],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967747,0.001376338,0.001114751,0.0001025912,0.00002045255,0.00001634208,0.0001773521,0.00005464729,0.0003627588],"genre_scores_gemma":[0.9981377,0.0004351696,0.0008278383,0.00002276545,0.00000689906,0.00001625262,0.0001469629,0.00001004381,0.0003964033],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001904004,"threshold_uncertainty_score":0.003785849,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006066017605990074,"score_gpt":0.2615761940088551,"score_spread":0.2555101764028651,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}