{"id":"W2918955800","doi":"10.3389/fcvm.2019.00018","title":"Autotaxin and Lipoprotein Metabolism in Calcific Aortic Valve Disease","year":2019,"lang":"en","type":"review","venue":"Frontiers in Cardiovascular Medicine","topic":"Sphingolipid Metabolism and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Institut universitaire de cardiologie et de pneumologie de Québec, Université Laval","keywords":"Autotaxin; Lysophosphatidic acid; Mendelian randomization; Aortic valve; Biochemistry; Lipoprotein; Chemistry; Inflammation; Apolipoprotein E; Internal medicine; Biology; Cell biology; Medicine; Disease; Cholesterol; Gene; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003203172,0.0003933222,0.0004446719,0.0008117487,0.0001696073,0.0005889242,0.0002384751,0.0009426218,0.0009411859],"category_scores_gemma":[0.000283635,0.000102809,0.0001800069,0.0007321792,0.000330605,0.000592239,0.0003418714,0.0009981685,0.000629689],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005181928,"about_ca_system_score_gemma":0.000640284,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005682972,"about_ca_topic_score_gemma":0.0008456954,"domain_scores_codex":[0.9999107,0.0000165212,0.00001345618,0.00002112393,0.00002544938,0.00001266502],"domain_scores_gemma":[0.9998816,0.00003606909,0.00002710395,0.000002118582,0.00002874944,0.00002433636],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003871533,0.0001096447,0.001972503,0.009846393,0.0001194009,0.001100762,0.0002138704,0.0005701982,0.01973358,0.0120653,0.05310125,0.90078],"study_design_scores_gemma":[0.00002395379,0.0002971531,0.006033773,0.001484781,0.0001410182,0.004190534,0.00012996,0.0003048612,0.002706383,0.005463059,0.9791915,0.00003303852],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0007068795,0.997005,0.0002241736,0.001067196,0.0003252531,0.000002803167,0.00001758625,0.000008068522,0.0006429257],"genre_scores_gemma":[0.004267084,0.9926963,0.0002731648,0.0005095185,0.001140954,0.000007046882,0.0000429066,0.000001933708,0.001061086],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.0009426218,"threshold_uncertainty_score":0.003759742,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02073730499708341,"score_gpt":0.2760500292092941,"score_spread":0.2553127242122107,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}