{"id":"W2919057129","doi":"10.1113/jp277306","title":"Impairments in left ventricular mitochondrial bioenergetics precede overt cardiac dysfunction and remodelling in Duchenne muscular dystrophy","year":2019,"lang":"en","type":"article","venue":"The Journal of Physiology","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph; Saint John Regional Hospital; York University","funders":"Brock University; Canadian Institutes of Health Research; St. Francis Xavier University; Heart and Stroke Foundation of Canada","keywords":"Duchenne muscular dystrophy; Cardiomyopathy; Dystrophin; Internal medicine; Mitochondrion; Bioenergetics; Muscular dystrophy; Skeletal muscle; Cardiology; Medicine; Creatine; Dilated cardiomyopathy; Heart failure; Endocrinology; Biology; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002842108,0.0003468552,0.0003714054,0.0003818519,0.0001342842,0.0003569572,0.0001692575,0.0004714902,0.001778924],"category_scores_gemma":[0.000365444,0.0003350341,0.000137851,0.0001201818,0.000356193,0.0002249744,0.0002394936,0.0006478374,0.0002313805],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003232259,"about_ca_system_score_gemma":0.0001022803,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008297703,"about_ca_topic_score_gemma":0.001702257,"domain_scores_codex":[0.9998482,0.00002745228,0.00002118119,0.0000411463,0.00003594863,0.00002591783],"domain_scores_gemma":[0.9994974,0.0001016869,0.0001793981,0.00003044494,0.00003754296,0.0001534594],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007265816,0.0001094484,0.02807679,0.00008130357,0.00001590517,0.0005017787,0.00006792605,0.0002162452,0.9683165,0.00003285704,0.00008150876,0.001773275],"study_design_scores_gemma":[0.00004056417,0.001914984,0.7990093,0.00004430773,0.00004137164,0.001847007,0.0002231757,0.001040441,0.1948026,0.00009092344,0.0009288818,0.00001645941],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973878,0.001050441,0.00072146,0.00003572871,0.00001070185,0.00001593717,0.000221097,0.00002457843,0.0005323331],"genre_scores_gemma":[0.9980094,0.0003287435,0.0003990235,0.00005766501,0.000005547216,0.00002624477,0.0003105073,0.000005506326,0.0008573167],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001778924,"threshold_uncertainty_score":0.005951107,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003677991696293938,"score_gpt":0.2049991110280749,"score_spread":0.201321119331781,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}