{"id":"W2919065874","doi":"10.3389/fendo.2019.00093","title":"Insulin/IGF-1R, SIRT1, and FOXOs Pathways—An Intriguing Interaction Platform for Bone and Osteosarcoma","year":2019,"lang":"en","type":"article","venue":"Frontiers in Endocrinology","topic":"FOXO transcription factor regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":75,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; Stollery Children's Hospital","funders":"Stollery Children’s Hospital Foundation; Children's Hospital Foundation; Austrian Science Fund; Women and Children's Health Research Institute; Children's Health Research Institute; Cancer Research Institute","keywords":"PI3K/AKT/mTOR pathway; Signal transduction; Biology; Protein kinase B; Insulin receptor; Cancer research; Transcription factor; Insulin-like growth factor 1 receptor; Cell biology; Osteosarcoma; Growth factor; Insulin; Endocrinology; Genetics; Insulin resistance; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000196326,0.0004004417,0.0003647116,0.0005151387,0.0004130006,0.000678007,0.0002478985,0.0004804211,0.001839001],"category_scores_gemma":[0.0001037787,0.0001468622,0.0004585889,0.0003732498,0.0004574319,0.0006257443,0.0006546367,0.0007781227,0.0003142408],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003304286,"about_ca_system_score_gemma":0.0004270823,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005335642,"about_ca_topic_score_gemma":0.001095307,"domain_scores_codex":[0.9998803,0.00001581366,0.000007138706,0.00002997967,0.00002631299,0.00004044383],"domain_scores_gemma":[0.9999251,0.000004348669,0.00002036392,0.000003616144,0.00001385524,0.00003270606],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001887156,0.0004512506,0.01894497,0.004153098,0.0005215289,0.005461395,0.0008347041,0.001176518,0.5175951,0.05562341,0.03227268,0.3610783],"study_design_scores_gemma":[0.0004311337,0.002053948,0.1719653,0.0008760369,0.0008443741,0.01020922,0.002499506,0.006851661,0.09656638,0.05804045,0.6494135,0.000248308],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.3036495,0.6285542,0.01768049,0.01624219,0.003367069,0.0001091678,0.001370651,0.000520284,0.02850641],"genre_scores_gemma":[0.7897275,0.1819512,0.007080866,0.003226749,0.001804775,0.0001107312,0.001352907,0.00003941182,0.01470573],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.001839001,"threshold_uncertainty_score":0.006152093,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01326423040347398,"score_gpt":0.2382973794949947,"score_spread":0.2250331490915208,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}