{"id":"W2919065874","doi":"10.3389/fendo.2019.00093","title":"Insulin/IGF-1R, SIRT1, and FOXOs Pathways—An Intriguing Interaction Platform for Bone and Osteosarcoma","year":2019,"lang":"en","type":"article","venue":"Frontiers in Endocrinology","topic":"FOXO transcription factor regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":75,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; Stollery Children's Hospital","funders":"Stollery Children’s Hospital Foundation; Children's Hospital Foundation; Austrian Science Fund; Women and Children's Health Research Institute; Children's Health Research Institute; Cancer Research Institute","keywords":"PI3K/AKT/mTOR pathway; Signal transduction; Biology; Protein kinase B; Insulin receptor; Cancer research; Transcription factor; Insulin-like growth factor 1 receptor; Cell biology; Osteosarcoma; Growth factor; Insulin; Endocrinology; Genetics; Insulin resistance; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007969296,0.000151501,0.0002140936,0.0001614001,0.00004568121,0.0000212705,0.00007226105,0.0001640567,0.000006281135],"category_scores_gemma":[0.00004347519,0.0001613241,0.00003780854,0.00004702458,0.0000847617,0.00003102408,0.00005101374,0.0001214597,0.000001965249],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000332892,"about_ca_system_score_gemma":0.00002114535,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002026773,"about_ca_topic_score_gemma":0.00008146479,"domain_scores_codex":[0.9989749,0.00003718501,0.0002405767,0.0004012474,0.00005463485,0.0002914304],"domain_scores_gemma":[0.9996046,0.00001575987,0.00007816053,0.0002047503,0.00003908461,0.00005767904],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001492784,0.000126243,0.1478576,0.0001417717,0.00009864243,0.000009505279,0.0006648895,0.0001012594,0.6956369,0.002109872,0.0009500211,0.1508105],"study_design_scores_gemma":[0.02386716,0.007127646,0.3047534,0.0001354709,0.0001301816,0.0008285007,0.005753043,0.01488543,0.3727082,0.008823518,0.2590345,0.001952911],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9916937,0.001382259,0.005156792,0.0001470663,0.0009625198,0.0004707042,0.00001951671,0.00002062862,0.000146789],"genre_scores_gemma":[0.9949478,0.000264179,0.004245917,0.00009289325,0.00008861917,0.00004381706,0.0001920855,0.00002205086,0.0001026312],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3229286,"threshold_uncertainty_score":0.6578606,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01326423040347398,"score_gpt":0.2382973794949947,"score_spread":0.2250331490915208,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}