{"id":"W2919205573","doi":"10.1038/s41598-019-40518-5","title":"Maintenance of MYC expression promotes de novo resistance to BET bromodomain inhibition in castration-resistant prostate cancer","year":2019,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Stand Up To Cancer; Oregon Health and Science University; U.S. Department of Defense; University of British Columbia; American Association for Cancer Research; Prostate Cancer Foundation; Movember Foundation; Oregon Clinical and Translational Research Institute; Prospect Creek Foundation; National Cancer Institute; Entertainment Industry Foundation; National Institutes of Health; National Center for Advancing Translational Sciences; Hope Foundation","keywords":"Bromodomain; Prostate cancer; Cancer research; Cancer; Resistance (ecology); Prostate; Biology; Medicine; Castration; Bioinformatics; Epigenetics; Internal medicine; Gene; Genetics; Hormone","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001450313,0.0001805835,0.0003383816,0.0002542267,0.0001440132,0.000393861,0.0001788795,0.0002076178,0.001238144],"category_scores_gemma":[0.000129079,0.0001642312,0.0002371776,0.0001869648,0.000144706,0.0001374764,0.0001483764,0.0006324837,0.0003938787],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002811146,"about_ca_system_score_gemma":0.0001724401,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001007676,"about_ca_topic_score_gemma":0.001348687,"domain_scores_codex":[0.9998525,0.00002482131,0.00001631548,0.00002405727,0.00004737376,0.00003485512],"domain_scores_gemma":[0.9998757,0.00002682135,0.00002401017,0.00001828185,0.00001213655,0.00004312016],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000101668,0.0000640359,0.0002580157,0.00001534033,0.00000520198,0.00003702168,0.00001255439,0.00006800334,0.9983879,0.00005966361,0.00005413009,0.0009365056],"study_design_scores_gemma":[0.00003537768,0.0009287213,0.01659069,0.000004495289,0.00001867276,0.0005999572,0.00005169778,0.002661995,0.9759044,0.00004450409,0.003150654,0.00000875205],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964804,0.001139413,0.0008765619,0.00007022142,0.00002043517,0.00001929213,0.0002944602,0.00007067599,0.001028654],"genre_scores_gemma":[0.9969411,0.0003798639,0.0005065359,0.00003253723,0.000005110895,0.00001264302,0.0003724973,0.00001622063,0.001733444],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001238144,"threshold_uncertainty_score":0.004141986,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006238654480455306,"score_gpt":0.2425231728116937,"score_spread":0.2362845183312384,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}