{"id":"W2919274753","doi":"10.1172/jci.insight.122728","title":"BAFF-driven B cell hyperplasia underlies lung disease in common variable immunodeficiency","year":2019,"lang":"en","type":"article","venue":"JCI Insight","topic":"Immunodeficiency and Autoimmune Disorders","field":"Immunology and Microbiology","cited_by":86,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Svenska Läkaresällskapet; Rare Disease Foundation; National Institute of Allergy and Infectious Diseases; Icahn School of Medicine at Mount Sinai; National Institutes of Health; Vetenskapsrådet; School of Medicine, Boston University; Memorial Sloan-Kettering Cancer Center","keywords":"Common variable immunodeficiency; Immunodeficiency; Disease; B-cell activating factor; Lung disease; Hyperplasia; Medicine; Immunology; Lung; Cancer research; Internal medicine; B cell; Immune system; Antibody","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0001993982,0.0003288938,0.0004769019,0.0002521074,0.0002593349,0.00004435528,0.0005729008,0.000265871,0.001858284],"category_scores_gemma":[0.00002493673,0.0003026342,0.0001383659,0.0004699953,0.0001921985,0.0003070319,0.0001976168,0.0005590807,0.002672466],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001009845,"about_ca_system_score_gemma":0.0001878488,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003427045,"about_ca_topic_score_gemma":0.000008106156,"domain_scores_codex":[0.997978,0.0002105689,0.0005206171,0.0005041542,0.00008072988,0.0007059613],"domain_scores_gemma":[0.9989155,0.0001527517,0.0001465198,0.0007252473,0.00004472326,0.00001528936],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0008880275,0.003785071,0.1845554,0.0004272405,0.0001653757,0.00005539293,0.006897187,0.007235651,0.7563758,0.0344003,0.001359468,0.003855039],"study_design_scores_gemma":[0.01693175,0.0007843425,0.2964738,0.0008015135,0.0002971698,0.00007027248,0.005609342,0.006332492,0.03663471,0.003913639,0.6284609,0.003690079],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8915773,0.04790043,0.000074435,0.0001286052,0.001455491,0.0004863194,0.00002526903,0.0001231629,0.05822898],"genre_scores_gemma":[0.9901429,0.0002388931,0.00002372642,0.0002572752,0.000003324001,0.00003490125,0.0002051586,0.00003564788,0.009058161],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7197412,"threshold_uncertainty_score":0.9999426,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004597713582353131,"score_gpt":0.2023273296977497,"score_spread":0.1977296161153965,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}