{"id":"W2919274753","doi":"10.1172/jci.insight.122728","title":"BAFF-driven B cell hyperplasia underlies lung disease in common variable immunodeficiency","year":2019,"lang":"en","type":"article","venue":"JCI Insight","topic":"Immunodeficiency and Autoimmune Disorders","field":"Immunology and Microbiology","cited_by":86,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Svenska Läkaresällskapet; Rare Disease Foundation; National Institute of Allergy and Infectious Diseases; Icahn School of Medicine at Mount Sinai; National Institutes of Health; Vetenskapsrådet; School of Medicine, Boston University; Memorial Sloan-Kettering Cancer Center","keywords":"Common variable immunodeficiency; Immunodeficiency; Disease; B-cell activating factor; Lung disease; Hyperplasia; Medicine; Immunology; Lung; Cancer research; Internal medicine; B cell; Immune system; Antibody","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003503235,0.0002067895,0.0002542948,0.000866066,0.0002228872,0.0002923007,0.0002622953,0.0002951723,0.0007837669],"category_scores_gemma":[0.0006700426,0.00008751543,0.0001552322,0.0004390933,0.0003852105,0.0002009482,0.000228605,0.0002491073,0.0001201697],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003054264,"about_ca_system_score_gemma":0.0001590001,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009436327,"about_ca_topic_score_gemma":0.0009975344,"domain_scores_codex":[0.9997959,0.00003814833,0.00003011388,0.00004307077,0.00005787025,0.00003483241],"domain_scores_gemma":[0.9996283,0.0001042162,0.0001660029,0.00001867208,0.00005072124,0.00003207527],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005501185,0.00007125539,0.8344786,0.0005214535,0.0001540566,0.0162582,0.0003446118,0.0002374883,0.09947753,0.0005733322,0.0006170211,0.04671639],"study_design_scores_gemma":[0.00002716282,0.0003918452,0.8908557,0.0001267988,0.0001989094,0.0879594,0.0003260183,0.0005171321,0.01302721,0.0007189224,0.005837021,0.0000138695],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9783934,0.01866204,0.0008864941,0.0001231579,0.00001251985,0.00002637912,0.0001708396,0.00003248148,0.001692798],"genre_scores_gemma":[0.9973832,0.001888636,0.0003318923,0.00007775675,0.00002668935,0.000006491478,0.0001527898,0.000002039979,0.0001306098],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009436327,"threshold_uncertainty_score":0.002621949,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004597713582353131,"score_gpt":0.2023273296977497,"score_spread":0.1977296161153965,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}