{"id":"W2919299825","doi":"10.1182/blood-2018-99-115068","title":"Metformintreatment Overcomes ATRA-Resistance in Acute Promyelocytic Leukemia and Increases FOXO3A Expression","year":2018,"lang":"en","type":"article","venue":"Blood","topic":"Retinoids in leukemia and cellular processes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Acute promyelocytic leukemia; Arsenic trioxide; Medicine; Tretinoin; Idarubicin; Internal medicine; Metformin; Cancer research; Retinoic acid; Apoptosis; Leukemia; Viability assay; Peripheral blood mononuclear cell; Oncology; Immunology; Cell culture; Biology; Cytarabine; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001124981,0.0002149982,0.0002645209,0.0002478439,0.0001686002,0.000190799,0.0001571868,0.0001606633,0.00155795],"category_scores_gemma":[0.00008777661,0.00008675606,0.0002628175,0.0001580041,0.000112031,0.000106234,0.0001640787,0.0004976632,0.0002319567],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00014203,"about_ca_system_score_gemma":0.0002236384,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003022147,"about_ca_topic_score_gemma":0.0008111418,"domain_scores_codex":[0.999938,0.000009547876,0.000007681715,0.00001102517,0.0000159648,0.00001785232],"domain_scores_gemma":[0.9999492,0.000005136202,0.00001458252,0.000005419894,0.000005264998,0.00002049211],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002385674,0.0005020566,0.003016026,0.000154638,0.00003497949,0.0001672942,0.00003934891,0.0002256188,0.9769051,0.0001048612,0.0005735172,0.01589092],"study_design_scores_gemma":[0.001096147,0.01435464,0.06049473,0.00003942709,0.0001574584,0.001435555,0.0001746513,0.001737018,0.9033478,0.0001156413,0.01703177,0.000015192],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972605,0.001350523,0.000311663,0.0000862907,0.00003932663,0.00003847025,0.0002592095,0.00004513931,0.0006088971],"genre_scores_gemma":[0.9963793,0.0009181863,0.0006480898,0.000050218,0.00001503057,0.00004842391,0.0007351307,0.00000563297,0.001200064],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00155795,"threshold_uncertainty_score":0.00521183,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004692256100860804,"score_gpt":0.2266431342068718,"score_spread":0.221950878106011,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}