{"id":"W2919355321","doi":"10.1101/569301","title":"Genetic Polymorphisms and Molecular Mechanisms Mediating Oncolytic Potency of Reovirus Strains","year":2019,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Izaak Walton Killam Health Centre; Dalhousie University; University of Alberta","funders":"","keywords":"Oncolytic virus; Biology; Viral replication; Virology; Virus; Phenotype; Gene; Potency; Cell culture; In vitro; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004283078,0.0002675614,0.0001875617,0.0003780518,0.0001192808,0.0003750353,0.0002570312,0.0003387344,0.001087261],"category_scores_gemma":[0.0004356914,0.0001221495,0.0003199922,0.0001903692,0.0002665203,0.0001960183,0.0002492494,0.0005842321,0.0003087446],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002602648,"about_ca_system_score_gemma":0.0001791169,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005095551,"about_ca_topic_score_gemma":0.0004134765,"domain_scores_codex":[0.9996879,0.00008837607,0.00005185589,0.00005514312,0.00006335239,0.00005337111],"domain_scores_gemma":[0.9995937,0.0001528319,0.0001212549,0.00006322347,0.00003264217,0.00003628037],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008857892,0.0000247805,0.0004651083,0.00001035649,0.000006297594,0.0000196771,0.000008461691,0.00007957212,0.9985219,0.0001054869,0.00001136349,0.000658425],"study_design_scores_gemma":[0.00001058466,0.0002718476,0.003588684,0.000004306078,0.00001841739,0.0002397135,0.00002089754,0.0005955967,0.9946073,0.00006936434,0.0005677479,0.000005624685],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947118,0.0004152426,0.003687108,0.00003218011,0.000008489573,0.00003485149,0.0004359231,0.00004291391,0.000631588],"genre_scores_gemma":[0.9972988,0.0001275175,0.001725395,0.00001804056,0.000003347514,0.0000286801,0.0003798128,0.000029427,0.0003890519],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001087261,"threshold_uncertainty_score":0.003637195,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01174055572971696,"score_gpt":0.2424445533333882,"score_spread":0.2307039976036712,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}