{"id":"W2919429028","doi":"10.1097/dad.0000000000001390","title":"Global PD-L1 Signals and Tumor-Infiltrating Lymphocytes: Markers of Immunogenicity in Different Subsets of Merkel Cell Carcinoma and Potential Therapeutic Implications","year":2019,"lang":"en","type":"article","venue":"American Journal of Dermatopathology","topic":"Polyomavirus and related diseases","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Nova Scotia Health Authority; Dalhousie University","funders":"","keywords":"Merkel cell polyomavirus; Immunogenicity; Merkel cell carcinoma; Immunohistochemistry; Tumor microenvironment; Immune system; Immunotherapy; Immunology; Biology; Cancer research; Medicine; Pathology; Carcinoma","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001392658,0.000140933,0.0006693889,0.0001417508,0.0000236573,0.000004860958,0.00009000548,0.00004769608,0.00001681586],"category_scores_gemma":[0.00002128645,0.0001049032,0.0001218825,0.0001754406,0.0003939197,0.00005245818,0.00003967244,0.0001229028,4.97659e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004551969,"about_ca_system_score_gemma":0.0001759348,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001020635,"about_ca_topic_score_gemma":0.000001971961,"domain_scores_codex":[0.9987209,0.0001736568,0.0006399467,0.0001359587,0.0001351609,0.0001944129],"domain_scores_gemma":[0.9987852,0.0001010376,0.0007353957,0.0001557763,0.00009601321,0.0001265685],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006654355,0.0001741125,0.8555597,0.00006903507,0.00005579913,0.00009466898,0.0001647167,0.00001616664,0.1404141,0.00001850401,0.000004996025,0.002762756],"study_design_scores_gemma":[0.002180877,0.0009475556,0.9792166,0.00008768172,0.0002453648,0.008602431,0.001055198,0.0001377936,0.007339144,0.00009930255,0.000002646614,0.00008536859],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929563,0.006408095,0.00007274235,0.0002006887,0.00004676457,0.0001448522,0.00002947025,0.000003118644,0.0001379113],"genre_scores_gemma":[0.9992433,0.0003777317,0.0001636442,0.0001853784,0.00001426844,0.00000162923,0.000002123405,0.000009345372,0.000002615221],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1330749,"threshold_uncertainty_score":0.4277829,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005389033239554653,"score_gpt":0.240921433404951,"score_spread":0.2355324001653963,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}