{"id":"W2919501631","doi":"10.1182/blood-2018-99-117482","title":"Identification of Specificity Groups in Myeloma Patients T Cell Receptor (TCR) Repertoire through Single Cell TCR Sequencing","year":2018,"lang":"en","type":"article","venue":"Blood","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research; University of Calgary","funders":"","keywords":"Daratumumab; T-cell receptor; Biology; T cell; Pomalidomide; CD8; Cytotoxic T cell; Antigen; Multiple myeloma; Immunology; Immune system; Molecular biology; Cancer research; Lenalidomide; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001390153,0.0001217192,0.000179289,0.0004822947,0.0001266109,0.0002865867,0.0001161742,0.0002162944,0.001323958],"category_scores_gemma":[0.000261078,0.00009403554,0.0001432866,0.0002580458,0.00009064468,0.00008301539,0.000159883,0.000231478,0.0003352731],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001086259,"about_ca_system_score_gemma":0.0001044852,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003351913,"about_ca_topic_score_gemma":0.0004624083,"domain_scores_codex":[0.999881,0.00001270824,0.000009603402,0.00004579972,0.00003113114,0.00001967688],"domain_scores_gemma":[0.9998889,0.00003145251,0.00002511356,0.00001069667,0.00002723572,0.00001660019],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.000376612,0.00002527517,0.02378704,0.00005177973,0.00001452239,0.0001760266,0.0001316655,0.0002515396,0.9608302,0.00006203141,0.0001251835,0.0141681],"study_design_scores_gemma":[0.00004731802,0.001133457,0.2497819,0.00002818926,0.0001504198,0.006286289,0.0004092498,0.00950011,0.7262309,0.0004247399,0.00599265,0.00001483293],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933503,0.0004872274,0.004753264,0.00003281073,0.00000634864,0.00002707259,0.000565576,0.00008483862,0.000692499],"genre_scores_gemma":[0.9913692,0.0002219159,0.006834952,0.00004797953,0.000007021339,0.00003479448,0.0008256895,0.0000177241,0.0006407243],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001323958,"threshold_uncertainty_score":0.004429102,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03047022468498453,"score_gpt":0.2701299999729085,"score_spread":0.239659775287924,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}