{"id":"W2919528979","doi":"10.1016/s0735-1097(19)32669-5","title":"APABETALONE, AN EPIGENETIC BET INHIBITOR IN A PHASE 3 TRIAL, INHIBITS VASCULAR INFLAMMATION AND CELLULAR ADHESION LEADING TO BENEFICIAL OUTCOMES IN CVD PATIENTS","year":2019,"lang":"en","type":"article","venue":"Journal of the American College of Cardiology","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"Resverlogix (Canada); University of Calgary","funders":"","keywords":"Bromodomain; Medicine; Epigenetics; Inflammation; BET inhibitor; Disease; Internal medicine; Oncology; Pharmacology; Bioinformatics; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006448418,0.0005716932,0.0008564893,0.0002007912,0.000185736,0.0005119677,0.0002558383,0.0003943242,0.002381052],"category_scores_gemma":[0.0003596252,0.0001539119,0.00063069,0.0001903534,0.000201648,0.0002337357,0.0001359169,0.001580285,0.0003013872],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002428588,"about_ca_system_score_gemma":0.0004697523,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005351732,"about_ca_topic_score_gemma":0.002278233,"domain_scores_codex":[0.9999038,0.00003291306,0.000006525645,0.00001310724,0.00001574511,0.00002791311],"domain_scores_gemma":[0.9998287,0.00003823401,0.00003489956,0.00001048167,0.00001769605,0.0000699998],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.4271733,0.01847221,0.00950551,0.002192153,0.003869665,0.0003472469,0.0001447861,0.002499628,0.1170769,0.0009602529,0.01078587,0.4069725],"study_design_scores_gemma":[0.549988,0.3272849,0.06919955,0.0002800872,0.003440023,0.0009391943,0.0001972464,0.003895571,0.02391783,0.0014083,0.01936614,0.00008330277],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9745468,0.01744564,0.0009510181,0.00138194,0.0005385128,0.0004418355,0.0008864311,0.0001699217,0.00363788],"genre_scores_gemma":[0.9813743,0.01013422,0.001446734,0.001528991,0.000374014,0.0003474381,0.001216438,0.00002177401,0.003556083],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002381052,"threshold_uncertainty_score":0.007965446,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008039795544535438,"score_gpt":0.2555296924060142,"score_spread":0.2474898968614788,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}