{"id":"W2919541373","doi":"10.1182/blood-2018-99-110819","title":"The Integrated Stress Response Activity Marks Stem Cells in Normal Hematopoiesis and Leukemia","year":2018,"lang":"en","type":"article","venue":"Blood","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Integrated stress response; Biology; Haematopoiesis; Stem cell; Cell biology; Progenitor cell; CD34; Myeloid leukemia; Immunology; Translation (biology); Biochemistry; Messenger RNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009781907,0.0002471605,0.0001437288,0.00040312,0.0001475159,0.0002663247,0.00009426663,0.00017333,0.001033156],"category_scores_gemma":[0.00006328711,0.00008135996,0.0001199643,0.0003186429,0.0001884572,0.0001421892,0.0001999667,0.0001956573,0.0002462648],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002162898,"about_ca_system_score_gemma":0.000122652,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003774276,"about_ca_topic_score_gemma":0.0004285848,"domain_scores_codex":[0.9999344,0.000007078052,0.000005115487,0.00001610858,0.00002242191,0.00001479645],"domain_scores_gemma":[0.9999604,0.000002584142,0.00001430397,0.000002893218,0.000006370926,0.00001345793],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001385754,0.000006651382,0.001765012,0.00003149043,0.000004730965,0.00004897035,0.00002027386,0.00002223293,0.9963455,0.00007904412,0.00003000917,0.001507428],"study_design_scores_gemma":[0.00002554654,0.0004540761,0.2662218,0.00002610529,0.00003508733,0.001187253,0.0002157109,0.001143924,0.7227411,0.0005262366,0.007413943,0.00000918487],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944153,0.002372363,0.001538891,0.00004947609,0.00001225063,0.00002011948,0.0006256002,0.00004946656,0.0009165696],"genre_scores_gemma":[0.9943215,0.001156065,0.00163551,0.00004685227,0.0000118344,0.00002567817,0.001242801,0.00001123929,0.00154847],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001033156,"threshold_uncertainty_score":0.003456235,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004298278332668489,"score_gpt":0.2122135039216313,"score_spread":0.2079152255889628,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}