{"id":"W2919652673","doi":"10.1212/wnl.0000000000007175","title":"Does reducing blood pressure and cholesterol provide any HOPE for preventing cognitive decline and dementia?","year":2019,"lang":"en","type":"letter","venue":"Neurology","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Medical Research Council; H. Lundbeck A/S; Medical Research Council; Eisai; TauRx Pharmaceuticals; National Health and Medical Research Council; Amgen","keywords":"Digit symbol substitution test; Cognitive decline; Medicine; Blood pressure; Dementia; Internal medicine; Cognition; Placebo; Hydrochlorothiazide; Cardiology; Physical therapy; Psychiatry; Pathology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01637547,0.0008044201,0.003193377,0.0008427905,0.0008613159,0.003392823,0.002364119,0.007579597,0.009677936],"category_scores_gemma":[0.0427294,0.000414853,0.001362986,0.0009571858,0.003803784,0.005074246,0.001029027,0.006074104,0.002859299],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001070762,"about_ca_system_score_gemma":0.00251893,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002225588,"about_ca_topic_score_gemma":0.00499489,"domain_scores_codex":[0.9959083,0.001968685,0.0003740148,0.0003586502,0.001169154,0.0002212249],"domain_scores_gemma":[0.9571274,0.02882626,0.005298558,0.001870813,0.004353328,0.002523693],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.03035817,0.001581873,0.01737287,0.009357777,0.005188953,0.0003466739,0.0004566871,0.0002776403,0.001286109,0.01293559,0.2291018,0.6917358],"study_design_scores_gemma":[0.02333724,0.01218106,0.08130911,0.0322824,0.0112337,0.0009712552,0.003005326,0.002834388,0.002565085,0.1032953,0.7265254,0.0004598051],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.01077324,0.3745483,0.0005124126,0.5804865,0.02650124,0.0001008711,0.0005186615,0.00004334498,0.006515496],"genre_scores_gemma":[0.108899,0.3909545,0.001337864,0.319083,0.1742775,0.0001913765,0.0004257498,0.0000732035,0.004757741],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.01637547,"threshold_uncertainty_score":0.08660281,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01432159054929206,"score_gpt":0.2945687678864121,"score_spread":0.28024717733712,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}