{"id":"W2919755724","doi":"10.3389/fphar.2019.00189","title":"Experimental Pharmacology in Transgenic Rodent Models of Alzheimer’s Disease","year":2019,"lang":"en","type":"article","venue":"Frontiers in Pharmacology","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Merck Canada; National Institute on Aging; Consortium canadien en neurodégénérescence associée au vieillissement","keywords":"Genetically modified mouse; Disease; Neuroscience; Transgene; Medicine; Pharmacology; Pathology; Psychology; Biology; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001674632,0.0002419512,0.0006420903,0.0005467695,0.00002112482,0.000003167997,0.000179228,0.0001103337,0.001530471],"category_scores_gemma":[0.000002849172,0.0002361462,0.0001772415,0.00031447,0.0001909334,0.0001700841,0.00006742847,0.0003082679,0.00005325397],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002540702,"about_ca_system_score_gemma":0.0004114294,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006051219,"about_ca_topic_score_gemma":0.000001957438,"domain_scores_codex":[0.9978918,0.0002226824,0.0004621435,0.0004833406,0.0003025795,0.0006374823],"domain_scores_gemma":[0.999187,0.00003414083,0.00008209118,0.0001970062,0.00004437149,0.0004553965],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.03228174,0.01725743,0.7477127,0.0004244218,0.01812309,0.003176822,0.001746927,0.005458574,0.1267572,0.0001844793,0.043847,0.003029541],"study_design_scores_gemma":[0.1023805,0.003006371,0.1265928,0.0002127896,0.0052749,0.00004575433,0.001528786,0.08442435,0.6721601,0.001630573,0.001565139,0.001177779],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9465576,0.04852735,0.00006663993,0.0004647555,0.001493163,0.001837545,0.00004591718,0.00002707587,0.000979987],"genre_scores_gemma":[0.9977429,0.000784532,0.0004517168,0.0004777597,0.00007811483,0.0003081873,0.00005837835,0.00003598773,0.00006242298],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6211199,"threshold_uncertainty_score":0.9993823,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0334948663926005,"score_gpt":0.3560171228262223,"score_spread":0.3225222564336218,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}