{"id":"W2919771415","doi":"10.1111/bph.14641","title":"A proof‐of‐concept, Phase 2 clinical trial of the gastrointestinal safety of a hydrogen sulfide‐releasing anti‐inflammatory drug","year":2019,"lang":"en","type":"article","venue":"British Journal of Pharmacology","topic":"Sulfur Compounds in Biology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":114,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Research, Development and Innovation Office","keywords":"Naproxen; Medicine; Analgesic; Gastroenterology; Drug; Internal medicine; Nausea; Toxicity; Antipyretic; Incidence (geometry); Pharmacology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002300746,0.00217109,0.001879402,0.0005150781,0.0005221089,0.001157784,0.001449884,0.002523734,0.008831084],"category_scores_gemma":[0.001167378,0.0009063217,0.001113846,0.0003255364,0.001343537,0.001255325,0.0003884192,0.002848065,0.001277626],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006392883,"about_ca_system_score_gemma":0.00182985,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003627163,"about_ca_topic_score_gemma":0.0007684343,"domain_scores_codex":[0.9993327,0.0003259512,0.0000235445,0.00009465496,0.00008223421,0.000140868],"domain_scores_gemma":[0.9991888,0.0001693393,0.0001735632,0.00005971557,0.00006825008,0.0003402453],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7183809,0.096353,0.001310289,0.002351818,0.0006906252,0.0005197165,0.0002427103,0.001037955,0.1283522,0.0004455702,0.005148551,0.04516661],"study_design_scores_gemma":[0.4909135,0.4986567,0.002479878,0.00004851784,0.0002008732,0.0002682502,0.00004113484,0.0004448663,0.004564968,0.0001712099,0.002186565,0.00002345834],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9737816,0.003703218,0.003295855,0.001098439,0.0006908435,0.01212301,0.002685905,0.0002249078,0.002396205],"genre_scores_gemma":[0.9621351,0.003796384,0.007224162,0.002152654,0.0008720167,0.01318622,0.00304484,0.00005724682,0.007531357],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008831084,"threshold_uncertainty_score":0.02954292,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01834894903829124,"score_gpt":0.3279949209954635,"score_spread":0.3096459719571723,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}