{"id":"W2919830364","doi":"10.1634/theoncologist.2018-0341","title":"Regulatory and Clinical Experiences with Biosimilar Filgrastim in the U.S., the European Union, Japan, and Canada","year":2019,"lang":"en","type":"article","venue":"The Oncologist","topic":"Neutropenia and Cancer Infections","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Health Science Centre","funders":"","keywords":"Biosimilar; Filgrastim; Medicine; European union; Business; Neutropenia; Internal medicine; International trade; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001169729,0.00007508665,0.0001281897,0.00001025321,0.000166935,0.00002287093,0.0001399153,0.00002202195,0.00003414531],"category_scores_gemma":[0.00003733395,0.00002705315,0.00001476703,0.00009745824,0.0006352573,0.00002285177,0.00004661581,0.0002311102,0.000003085025],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003588124,"about_ca_system_score_gemma":0.0002145448,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.05732076,"about_ca_topic_score_gemma":0.3840939,"domain_scores_codex":[0.9989522,0.0005170418,0.000139723,0.0001458749,0.0001275314,0.0001175925],"domain_scores_gemma":[0.9992822,0.0003280714,0.00005335707,0.0002782599,0.00002115983,0.00003697626],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001395132,0.00008956071,0.9518949,0.00001662901,0.00004891759,0.00005372809,0.004393747,0.000009897442,0.000100896,0.0003795399,0.03454335,0.008329324],"study_design_scores_gemma":[0.000640552,0.0005211952,0.929498,0.00002537274,0.00004444569,0.0001369638,0.0205919,0.000009462478,0.00002364586,0.00001143549,0.04844295,0.00005406419],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9676261,0.0002099906,0.000001781095,0.01662324,0.0001476143,0.0003350071,0.000001668496,0.000009362672,0.01504523],"genre_scores_gemma":[0.9959373,0.0001042509,0.000007590521,0.003334458,0.0001133329,0.00002002363,0.000001095334,0.000006202541,0.0004756788],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3267732,"threshold_uncertainty_score":0.9489566,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01838696689152592,"score_gpt":0.2894433573541078,"score_spread":0.2710563904625819,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}