{"id":"W2919872889","doi":"10.1128/msphere.00102-19","title":"Loss of the Two-Component System TctD-TctE in <i>Pseudomonas aeruginosa</i> Affects Biofilm Formation and Aminoglycoside Susceptibility in Response to Citric Acid","year":2019,"lang":"en","type":"article","venue":"mSphere","topic":"Bacterial biofilms and quorum sensing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Cystic Fibrosis Canada; Natural Sciences and Engineering Research Council of Canada; Government of Canada; Health Canada; University of Ottawa","keywords":"Citric acid; Pseudomonas aeruginosa; Biofilm; Tobramycin; Microbiology; Aminoglycoside; Mutant; Chemistry; Biochemistry; Biology; Bacteria; Antibiotics; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000141472,0.0002911657,0.0002316314,0.0001654966,0.0001702726,0.0003209304,0.0003454781,0.0004410513,0.001254483],"category_scores_gemma":[0.0002372868,0.0001620827,0.0002254153,0.0001382488,0.0003056862,0.0001932224,0.000228433,0.0007445148,0.0003827091],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005527317,"about_ca_system_score_gemma":0.0002704083,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002239996,"about_ca_topic_score_gemma":0.00241515,"domain_scores_codex":[0.9997306,0.00005020602,0.00003612313,0.00004210184,0.00008514537,0.00005587027],"domain_scores_gemma":[0.9997371,0.00007049373,0.0000733246,0.00002941405,0.00002758006,0.00006219952],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008086459,0.00003215323,0.00008272802,0.00001028042,0.000002626317,0.00002918965,0.000009065015,0.00003722101,0.9993935,0.00005032574,0.00001961289,0.0002524336],"study_design_scores_gemma":[0.000008686608,0.0002171625,0.002362605,0.000003635241,0.000007502964,0.0001112886,0.00002751911,0.000831626,0.995385,0.00002266103,0.001017191,0.00000525707],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965383,0.0003605408,0.001807922,0.000163861,0.00004823367,0.00001835215,0.0002844067,0.00005996357,0.0007183229],"genre_scores_gemma":[0.995771,0.000163117,0.0009623186,0.00006464063,0.000006378742,0.00002414762,0.0003829876,0.00003657567,0.002588791],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002239996,"threshold_uncertainty_score":0.004453957,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005240820347551511,"score_gpt":0.210179591997029,"score_spread":0.2049387716494775,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}