{"id":"W2919932567","doi":"10.1038/s41598-019-40045-3","title":"Hedgehog signaling in the airway epithelium of patients with chronic obstructive pulmonary disease","year":2019,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Hedgehog Signaling Pathway Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; St. Paul's Hospital","funders":"Merck","keywords":"PTCH1; Epithelium; Respiratory epithelium; Pathology; COPD; Biology; Gene knockdown; Medicine; Cancer research; Immunology; Internal medicine; Cell culture; Hedgehog; Cell biology; Signal transduction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006506203,0.0001501506,0.0001619923,0.00007482166,0.0001045547,0.00003466765,0.0002018516,0.00004833449,0.00002169349],"category_scores_gemma":[0.00009535654,0.0000983246,0.00007738757,0.0002776242,0.0002788231,0.000008515914,0.000100145,0.00008204733,0.00000732941],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002670779,"about_ca_system_score_gemma":0.0002152381,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001014397,"about_ca_topic_score_gemma":0.00001600721,"domain_scores_codex":[0.9982982,0.00007984669,0.0003331925,0.0006226275,0.0004022174,0.0002638735],"domain_scores_gemma":[0.998656,0.0000204937,0.0002383241,0.0008308285,0.0001984538,0.00005595385],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001014613,0.0001934893,0.7044473,0.0001013373,0.00003525916,0.0000885386,0.0004019747,0.001576881,0.2921666,0.00001285085,0.0002118634,0.0006624385],"study_design_scores_gemma":[0.0005836397,0.000333843,0.7286267,0.0001760224,0.00005586792,0.00002299351,0.0005142486,0.00007138342,0.2568585,0.0007110944,0.01153883,0.0005068248],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973086,0.0006465721,0.00003589916,0.00002819197,0.0009637651,0.0005066749,0.00001291397,0.000006303333,0.0004911064],"genre_scores_gemma":[0.9991646,0.000002739483,0.00006294749,0.00002070436,0.00005907873,0.00002738669,0.0001430425,0.00001568601,0.0005037534],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03530807,"threshold_uncertainty_score":0.4009561,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006238778387197461,"score_gpt":0.2116804252781794,"score_spread":0.2054416468909819,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}