{"id":"W2920058474","doi":"10.1016/j.mrgentox.2019.02.006","title":"Targets and mechanisms of chemically induced aneuploidy. Part 1 of the report of the 2017 IWGT workgroup on assessing the risk of aneugens for carcinogenesis and hereditary diseases","year":2019,"lang":"en","type":"review","venue":"Mutation Research/Genetic Toxicology and Environmental Mutagenesis","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":false,"ca_institutions":"Health Canada","funders":"","keywords":"Workgroup; Aneuploidy; Biology; Risk assessment; Genetics; Medicine; Gene; Computer science; Chromosome","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005550586,0.0002488869,0.0006284081,0.00006819502,0.000202767,0.000008393165,0.0003165377,0.0003808662,0.000007938948],"category_scores_gemma":[0.000212516,0.0001479916,0.0002462897,0.0001021757,0.0009438716,0.000004995176,0.0004311571,0.0001792761,1.437557e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002740799,"about_ca_system_score_gemma":0.0001626519,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002623994,"about_ca_topic_score_gemma":0.00001343259,"domain_scores_codex":[0.9978056,0.0006145046,0.0006065735,0.0004708767,0.0002729005,0.0002295285],"domain_scores_gemma":[0.998166,0.0003657452,0.0007421919,0.0006257086,0.00004054138,0.00005982928],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001937148,0.0004925764,0.01488744,0.007765194,0.001203098,0.00001463406,0.0001846791,0.0001613534,0.8392703,0.00006185092,0.0001960508,0.1355691],"study_design_scores_gemma":[0.001893061,0.002649037,0.2821856,0.002281738,0.005115251,0.0006270866,0.001335195,0.0002266681,0.688618,0.0008115362,0.01335043,0.0009063463],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7141986,0.2839466,0.00006601435,0.00002502895,0.00009727612,0.001104514,0.0005537427,0.000001011765,0.000007256409],"genre_scores_gemma":[0.6235645,0.3759758,0.0001231465,0.00001662208,0.00003444965,0.0001007754,0.0001034628,0.00002659649,0.00005454573],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2672982,"threshold_uncertainty_score":0.6034921,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0396056977900973,"score_gpt":0.3237290239815497,"score_spread":0.2841233261914524,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}