{"id":"W2920060756","doi":"10.1007/s41664-019-00087-y","title":"Interactions Between Hemin-Binding DNA Aptamers and Hemin–Graphene Nanosheets: Reduced Affinity but Unperturbed Catalytic Activity","year":2019,"lang":"en","type":"article","venue":"Journal of Analysis and Testing","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":false,"ca_institutions":"Simon Fraser University","funders":"China Scholarship Council; Natural Sciences and Engineering Research Council of Canada; National Natural Science Foundation of China","keywords":"Hemin; Aptamer; Graphene; DNA; Oligonucleotide; G-quadruplex; Chemistry; Deoxyribozyme; Ionic strength; Combinatorial chemistry; Biophysics; Biochemistry; Nanotechnology; Materials science; Enzyme; Heme; Biology; Organic chemistry; Molecular biology; Aqueous solution","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001693368,0.0002397932,0.0001746883,0.0001586185,0.0001554754,0.000240326,0.0003867215,0.0005060476,0.001316075],"category_scores_gemma":[0.000282365,0.0001540581,0.0001236939,0.0001292276,0.0001964597,0.0001981402,0.0001953887,0.0003843377,0.0002254871],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003392808,"about_ca_system_score_gemma":0.00009366967,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005959754,"about_ca_topic_score_gemma":0.0009886454,"domain_scores_codex":[0.99975,0.00003397266,0.0000102251,0.00005386491,0.00007914843,0.00007282781],"domain_scores_gemma":[0.9998723,0.0000521507,0.0000208346,0.00001393296,0.00001445395,0.00002625467],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008407777,0.00002059856,0.0001146161,0.00001336881,0.000006216399,0.00003729818,0.00001660073,0.0001222728,0.9987246,0.00006825508,0.00005321108,0.0007389103],"study_design_scores_gemma":[0.000005389139,0.000054526,0.0006300173,8.30647e-7,0.00000353366,0.00003426854,0.00001308513,0.000965206,0.9980123,0.00002254921,0.0002553707,0.000002866433],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977181,0.0001541786,0.001247736,0.00005814699,0.00001530378,0.000007696568,0.00004257372,0.00003386635,0.0007222721],"genre_scores_gemma":[0.9979412,0.00004451183,0.0008555438,0.00004591919,0.000003399138,0.000007381405,0.00006106472,0.000006216857,0.001034701],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001316075,"threshold_uncertainty_score":0.004402697,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01734259985802972,"score_gpt":0.2777908457709833,"score_spread":0.2604482459129536,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}