{"id":"W2920333731","doi":"10.1161/res.123.suppl_1.284","title":"Abstract 284: Loss of Cardiomyocyte General Control of Amino-Acid Synthesis 5-like 1 Expression Impairs Mitochondrial Function and Exacerbates Heart Failure Progression","year":2018,"lang":"en","type":"article","venue":"Circulation Research","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Manning Diversified Forest Products (Canada)","funders":"","keywords":"Mitochondrion; Internal medicine; Endocrinology; Heart failure; Biology; Muscle hypertrophy; Myocyte; Gene knockdown; Beta oxidation; Bioenergetics; Cardiac function curve; Pressure overload; Cardiomyopathy; Cell biology; Biochemistry; Medicine; Metabolism; Cardiac hypertrophy; Apoptosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001568302,0.0004836113,0.0004353545,0.0002271142,0.0002222743,0.000224036,0.0003138261,0.000479326,0.004819261],"category_scores_gemma":[0.00009875038,0.0001638931,0.0003359666,0.0001278229,0.0003683121,0.0002181189,0.0002964779,0.0009971173,0.001099559],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003074976,"about_ca_system_score_gemma":0.0002563303,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005495968,"about_ca_topic_score_gemma":0.000705726,"domain_scores_codex":[0.9998032,0.00002023045,0.00002470133,0.00005530121,0.00005225288,0.00004440604],"domain_scores_gemma":[0.9998492,0.00001215969,0.00004486269,0.00001363631,0.00001367963,0.00006646338],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002740974,0.00003764437,0.0001834996,0.0000843155,0.000007304331,0.0000678233,0.00001246572,0.00002666712,0.9981711,0.00005695977,0.0001799108,0.0008981696],"study_design_scores_gemma":[0.0001398458,0.001214437,0.02007728,0.00004194398,0.00006012439,0.000574435,0.0001148,0.001168193,0.9703953,0.0001222862,0.006077827,0.00001350488],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9842307,0.004484666,0.004432255,0.000797028,0.0003580106,0.00007574903,0.002397681,0.0003399287,0.002883972],"genre_scores_gemma":[0.9820638,0.001785869,0.002361173,0.0005148806,0.00005747319,0.0001606163,0.002311683,0.00007050236,0.0106739],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004819261,"threshold_uncertainty_score":0.0161221,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02288414453114686,"score_gpt":0.3104802497711851,"score_spread":0.2875961052400383,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}