{"id":"W2920406506","doi":"10.1016/j.ebiom.2019.02.037","title":"Liver-derived fibroblast growth factor 21 mediates effects of glucagon-like peptide-1 in attenuating hepatic glucose output","year":2019,"lang":"en","type":"article","venue":"EBioMedicine","topic":"Fibroblast Growth Factor Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":84,"is_retracted":false,"has_abstract":true,"ca_institutions":"Diabetes Canada; University of Toronto","funders":"Peking University; Natural Science Foundation of Beijing Municipality; National Natural Science Foundation of China; National Key Research and Development Program of China; AstraZeneca","keywords":"Liraglutide; FGF21; Exenatide; Endocrinology; Internal medicine; Glucagon-like peptide-1; Glucose homeostasis; Glucagon; Knockout mouse; Type 2 diabetes; Medicine; Biology; Diabetes mellitus; Insulin; Fibroblast growth factor; Insulin resistance; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002540198,0.0003088885,0.000478307,0.0002870131,0.0000336205,0.00001297797,0.0003828104,0.0002176547,0.0001058918],"category_scores_gemma":[0.0006617175,0.0002677039,0.0001140143,0.0003831546,0.0002165235,0.00001345148,0.0003018181,0.0002395272,0.0001118967],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000526025,"about_ca_system_score_gemma":0.0001184031,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002684585,"about_ca_topic_score_gemma":0.00005430869,"domain_scores_codex":[0.9977579,0.0001575771,0.0004826086,0.0005507121,0.0004884537,0.0005627932],"domain_scores_gemma":[0.9987605,0.0002116387,0.0001870046,0.0004944629,0.000159351,0.0001869936],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000125052,0.0001118604,0.03276039,0.001044126,0.00006901781,0.00002902695,0.0004069557,0.000004213945,0.964089,0.000004214664,0.0004015731,0.0009545129],"study_design_scores_gemma":[0.002454451,0.001727428,0.1476985,0.0006604234,0.00001399261,0.00001041022,0.0001253929,0.0002586051,0.8465009,0.00001516041,0.0002718105,0.0002629397],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973969,0.001044993,0.0001116658,0.0001398852,0.0003194891,0.0006944454,0.00002567887,0.00002103781,0.0002459141],"genre_scores_gemma":[0.998355,0.0001890506,0.0003191112,0.00008516407,0.0002072172,0.00002865805,0.0001841471,0.00005508895,0.0005765072],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1175882,"threshold_uncertainty_score":0.9999775,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007900379267138396,"score_gpt":0.2435872366115287,"score_spread":0.2356868573443903,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}