{"id":"W2920529134","doi":"10.3390/v11030206","title":"A Diacylglycerol Kinase Inhibitor, R-59-022, Blocks Filovirus Internalization in Host Cells","year":2019,"lang":"en","type":"article","venue":"Viruses","topic":"Viral Infections and Outbreaks Research","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Public Health Agency of Canada; Institute of Infection and Immunity; University of Ottawa","funders":"Canadian Institutes of Health Research","keywords":"Ebola virus; Internalization; Virology; Viral entry; Biology; Vero cell; Marburg virus; Diacylglycerol kinase; Viral replication; Cell biology; Virus; Kinase; Receptor; Protein kinase C","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0001647921,0.0001422843,0.0002388138,0.0003570612,0.00003898697,0.00004976176,0.00007953156,0.0001064782,0.00222508],"category_scores_gemma":[0.000061636,0.0001207767,0.00007805526,0.0004251775,0.00004436166,0.0001825292,0.00008231878,0.000273887,0.001480845],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001141762,"about_ca_system_score_gemma":0.0000746084,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001814222,"about_ca_topic_score_gemma":0.0001880332,"domain_scores_codex":[0.99885,0.00005418842,0.0002640763,0.0002690004,0.0002768261,0.0002858795],"domain_scores_gemma":[0.9994244,0.00006191123,0.0000499757,0.000267349,0.00007756297,0.0001188173],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004244642,0.0004576774,0.1961818,0.0000933257,0.00003325822,0.00008790358,0.0002044996,0.00005578225,0.7950668,0.0001258162,0.00347681,0.003791916],"study_design_scores_gemma":[0.003964575,0.0009801971,0.03365199,0.0004397281,0.00003497743,0.00003197086,0.0001674628,0.001527612,0.8514271,0.00004763371,0.107418,0.000308825],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992337,0.0002497999,0.0001092045,0.0001141388,0.0003850765,0.0004963738,0.00002007913,0.00006518701,0.006223162],"genre_scores_gemma":[0.9956697,0.0001689449,0.00004782328,0.0009968175,0.0001955569,0.0000306405,0.00001167685,0.00002861378,0.002850179],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1625298,"threshold_uncertainty_score":0.9992966,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02268920461563283,"score_gpt":0.3124729245283144,"score_spread":0.2897837199126816,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}