{"id":"W2920624653","doi":"10.1016/j.celrep.2019.02.026","title":"FMR1 Reactivating Treatments in Fragile X iPSC-Derived Neural Progenitors In Vitro and In Vivo","year":2019,"lang":"en","type":"article","venue":"Cell Reports","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Azrieli Foundation; Teva Pharmaceutical Industries","keywords":"FMR1; Chromatin; Biology; Chromosomal fragile site; Fragile X syndrome; Gene silencing; Cell biology; Induced pluripotent stem cell; Genetics; Gene; Embryonic stem cell; Fragile x","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000402571,0.0005509033,0.0004547822,0.0003241477,0.0001655078,0.0002721582,0.0003330615,0.000371988,0.001216492],"category_scores_gemma":[0.0001522056,0.0001593079,0.0003069806,0.0001520815,0.0002470512,0.0001768912,0.000194396,0.001052967,0.0003732586],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002481085,"about_ca_system_score_gemma":0.0002184444,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008821498,"about_ca_topic_score_gemma":0.001483647,"domain_scores_codex":[0.9997603,0.00004714864,0.00003861608,0.00006469345,0.00005537093,0.00003377692],"domain_scores_gemma":[0.9998653,0.0000390989,0.0000330529,0.00002814231,0.00001376832,0.00002057341],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006448755,0.00005432784,0.00006592635,0.00005158463,0.000007224346,0.00006571813,0.00002448294,0.0001708161,0.9977375,0.0001298096,0.00006656462,0.001561494],"study_design_scores_gemma":[0.000009488007,0.0002669283,0.0004867153,0.000005381321,0.00001833713,0.00008310097,0.00000835006,0.0003186443,0.9977284,0.00001899679,0.001053773,0.000001959373],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9757339,0.003171366,0.01385552,0.0001714839,0.0001397893,0.0001756091,0.001718033,0.0003134019,0.004720991],"genre_scores_gemma":[0.9784061,0.002737442,0.01134377,0.0001030083,0.00002901273,0.0002576827,0.001621286,0.00008124678,0.005420473],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001216492,"threshold_uncertainty_score":0.004069626,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005606210542460291,"score_gpt":0.208609096747572,"score_spread":0.2030028862051117,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}