{"id":"W2920624653","doi":"10.1016/j.celrep.2019.02.026","title":"FMR1 Reactivating Treatments in Fragile X iPSC-Derived Neural Progenitors In Vitro and In Vivo","year":2019,"lang":"en","type":"article","venue":"Cell Reports","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Azrieli Foundation; Teva Pharmaceutical Industries","keywords":"FMR1; Chromatin; Biology; Chromosomal fragile site; Fragile X syndrome; Gene silencing; Cell biology; Induced pluripotent stem cell; Genetics; Gene; Embryonic stem cell; Fragile x","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007644869,0.0001286576,0.0001329394,0.0000697021,0.00001344885,0.00001121116,0.00003984971,0.00008401179,0.000008751167],"category_scores_gemma":[0.0000197358,0.0001316056,0.00002405762,0.00009207365,0.00001699497,0.000004113878,0.00007501167,0.00007399093,0.000001073181],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002079679,"about_ca_system_score_gemma":0.00003817476,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008888655,"about_ca_topic_score_gemma":0.00007352162,"domain_scores_codex":[0.999034,0.00002735518,0.0002632173,0.0003897756,0.00007425171,0.000211369],"domain_scores_gemma":[0.9996881,0.000005746141,0.00008506524,0.0001720281,0.00000948339,0.00003960857],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003518991,0.0000738302,0.2488417,0.00001065165,0.000002441519,0.00009069186,0.00007765766,0.00004853926,0.7501778,3.195116e-8,0.00001075728,0.0006307434],"study_design_scores_gemma":[0.0004963637,0.00005168253,0.2187359,0.000009891215,0.000001506364,0.00002274352,0.0001071159,0.00006336094,0.78005,0.0000099518,0.0003299933,0.0001214317],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976838,0.0002256251,3.865293e-7,0.00001655679,0.0001075201,0.000331723,0.000001192509,0.000003408079,0.001629766],"genre_scores_gemma":[0.9993018,0.00007151334,0.0001243605,0.00005289114,0.000005954465,0.0000301488,0.00002811286,0.00001787098,0.0003673687],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03010574,"threshold_uncertainty_score":0.5366719,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005606210542460291,"score_gpt":0.208609096747572,"score_spread":0.2030028862051117,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}