{"id":"W2920658753","doi":"10.1016/j.jtho.2019.03.002","title":"Efficacy and Safety of Ceritinib (450 mg/d or 600 mg/d) With Food Versus 750-mg/d Fasted in Patients With ALK Receptor Tyrosine Kinase (ALK)–Positive NSCLC: Primary Efficacy Results From the ASCEND-8 Study","year":2019,"lang":"en","type":"article","venue":"Journal of Thoracic Oncology","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":72,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital","funders":"Merck Sharp and Dohme; Boehringer Ingelheim; Novartis Pharmaceuticals Corporation; Celgene; Roche; AbbVie; Merck; Novartis; Pfizer; Eli Lilly and Company; Bristol-Myers Squibb","keywords":"Medicine; Ceritinib; Internal medicine; Gastroenterology; Tolerability; Confidence interval; Adverse effect; Anaplastic lymphoma kinase; Pleural effusion","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004446661,0.0002829197,0.0009537429,0.000177043,0.00009228419,0.00002024952,0.0001739069,0.0001360366,0.00007651107],"category_scores_gemma":[0.0002683573,0.0001488207,0.00007588794,0.000408385,0.0001674199,0.000181993,0.00006968768,0.0005119755,0.000005650623],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006485767,"about_ca_system_score_gemma":0.0009343367,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000120194,"about_ca_topic_score_gemma":0.0002373719,"domain_scores_codex":[0.9975434,0.0004014659,0.0008765262,0.0003573763,0.0005270863,0.0002941334],"domain_scores_gemma":[0.9964439,0.00148659,0.000987818,0.0003694216,0.0005273152,0.0001849106],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.7462679,0.01236733,0.122267,0.00007781536,0.003356487,0.0003566248,0.01094248,0.0001019103,0.0007761461,0.000007656111,0.000553922,0.1029248],"study_design_scores_gemma":[0.1006459,0.06203966,0.8297837,0.0009363436,0.001516376,0.00004488331,0.002858258,0.000005643272,0.000217218,0.000001457288,0.001786995,0.0001635715],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937608,0.0002843611,0.00001265535,0.001709675,0.0004319429,0.002079474,0.0002980142,0.00001172338,0.001411339],"genre_scores_gemma":[0.9972976,0.0000669312,0.001884516,0.0001934862,0.0001714619,0.00001380943,0.0001555972,0.00003848928,0.0001780457],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7075167,"threshold_uncertainty_score":0.6068733,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01674658629506235,"score_gpt":0.3646053398538381,"score_spread":0.3478587535587757,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}