{"id":"W2920658753","doi":"10.1016/j.jtho.2019.03.002","title":"Efficacy and Safety of Ceritinib (450 mg/d or 600 mg/d) With Food Versus 750-mg/d Fasted in Patients With ALK Receptor Tyrosine Kinase (ALK)–Positive NSCLC: Primary Efficacy Results From the ASCEND-8 Study","year":2019,"lang":"en","type":"article","venue":"Journal of Thoracic Oncology","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":72,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital","funders":"Merck Sharp and Dohme; Boehringer Ingelheim; Novartis Pharmaceuticals Corporation; Celgene; Roche; AbbVie; Merck; Novartis; Pfizer; Eli Lilly and Company; Bristol-Myers Squibb","keywords":"Medicine; Ceritinib; Internal medicine; Gastroenterology; Tolerability; Confidence interval; Adverse effect; Anaplastic lymphoma kinase; Pleural effusion","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002081164,0.0006491115,0.002128631,0.0003901433,0.000252539,0.0005890322,0.0004737749,0.0006867085,0.001155532],"category_scores_gemma":[0.001409215,0.0003207732,0.001242559,0.0002941304,0.000680954,0.0006526417,0.0002774087,0.001217543,0.0002597276],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007715605,"about_ca_system_score_gemma":0.0005101575,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005111507,"about_ca_topic_score_gemma":0.0009391467,"domain_scores_codex":[0.9993244,0.0003228606,0.00006889924,0.0001131189,0.0001061498,0.00006459485],"domain_scores_gemma":[0.9991703,0.0001614849,0.0003166574,0.00005236293,0.00005710015,0.0002420561],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9281143,0.005888806,0.0124957,0.0004862066,0.001281713,0.00007552915,0.00007333743,0.001017202,0.007638908,0.00004848002,0.0006113534,0.04226842],"study_design_scores_gemma":[0.4137677,0.483473,0.09177707,0.00005848098,0.002192202,0.0003709959,0.00007095763,0.002220947,0.004476568,0.0001552099,0.001373608,0.00006317684],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974416,0.001621777,0.0001047762,0.00007845099,0.00003881284,0.000152682,0.000217262,0.00001925038,0.0003254951],"genre_scores_gemma":[0.9985558,0.000447066,0.0001878065,0.00009355743,0.00005513223,0.00009975999,0.0003589037,0.000004176801,0.000197774],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002128631,"threshold_uncertainty_score":0.01100641,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01674658629506235,"score_gpt":0.3646053398538381,"score_spread":0.3478587535587757,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}