{"id":"W2920815711","doi":"10.1002/anie.201900585","title":"Targeting the Small GTPase Superfamily through Their Regulatory Proteins","year":2019,"lang":"en","type":"review","venue":"Angewandte Chemie International Edition","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":143,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Novartis Pharma; Innovative Medicines Initiative; Ontario Ministry of Economic Development and Innovation; Wellcome Trust; European Federation of Pharmaceutical Industries and Associations; Merck KGaA; Ministero dello Sviluppo Economico; Alzheimer’s Research UK; Genome Canada; Fundação de Amparo à Pesquisa do Estado de São Paulo; Diamond Light Source; Pfizer","keywords":"GTPase; Guanine nucleotide exchange factor; Ras superfamily; Rab; GTP-binding protein regulators; Biology; Small GTPase; GTPase-activating protein; Cell biology; Small molecule; Computational biology; Effector; GTP'; G protein; Biochemistry; Signal transduction","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003801467,0.0004537188,0.0004980831,0.00006784563,0.0001580694,0.00009518136,0.0005911199,0.0004784203,0.0001498147],"category_scores_gemma":[0.0001750925,0.0003187448,0.0005359692,0.0001228536,0.0001142829,0.00001960167,0.0002274968,0.0003590729,0.0000728073],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001152742,"about_ca_system_score_gemma":0.0002698,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001564963,"about_ca_topic_score_gemma":0.000003372623,"domain_scores_codex":[0.9981045,0.0001099469,0.0005550844,0.0006166166,0.0003313708,0.0002824975],"domain_scores_gemma":[0.998676,0.00005029728,0.0004424794,0.0005316564,0.0002409912,0.00005860293],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002396268,0.0005859805,0.00001770658,0.01334755,0.003071433,0.00004859236,0.0004748343,0.0002182165,0.3338061,0.002320949,0.1302106,0.5156583],"study_design_scores_gemma":[0.0002155968,0.00003571643,0.000001664072,0.001539279,0.0001171077,0.00003254273,0.00003284424,0.00001337742,0.1442574,0.000129183,0.8532903,0.000335102],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001093646,0.9889938,0.005547096,0.0001848609,0.001482432,0.001133409,0.0003568724,0.00004409263,0.00214804],"genre_scores_gemma":[0.0008517971,0.9804028,0.0004619511,0.0004131309,0.005808297,0.0004367364,0.009792936,0.00009431582,0.001738017],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.7230796,"threshold_uncertainty_score":0.9999264,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04346767454886808,"score_gpt":0.2909121439826024,"score_spread":0.2474444694337343,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}