{"id":"W2920815711","doi":"10.1002/anie.201900585","title":"Targeting the Small GTPase Superfamily through Their Regulatory Proteins","year":2019,"lang":"en","type":"review","venue":"Angewandte Chemie International Edition","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":143,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Novartis Pharma; Innovative Medicines Initiative; Ontario Ministry of Economic Development and Innovation; Wellcome Trust; European Federation of Pharmaceutical Industries and Associations; Merck KGaA; Ministero dello Sviluppo Economico; Alzheimer’s Research UK; Genome Canada; Fundação de Amparo à Pesquisa do Estado de São Paulo; Diamond Light Source; Pfizer","keywords":"GTPase; Guanine nucleotide exchange factor; Ras superfamily; Rab; GTP-binding protein regulators; Biology; Small GTPase; GTPase-activating protein; Cell biology; Small molecule; Computational biology; Effector; GTP'; G protein; Biochemistry; Signal transduction","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002717911,0.0006678187,0.0005747569,0.001123984,0.0002034314,0.0006361345,0.0005442561,0.0005646346,0.003923822],"category_scores_gemma":[0.0002163263,0.0002362684,0.0002632037,0.001104896,0.0003137546,0.0008944516,0.0005954667,0.001255484,0.005317769],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004823575,"about_ca_system_score_gemma":0.0004627368,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004800835,"about_ca_topic_score_gemma":0.0006860086,"domain_scores_codex":[0.9998908,0.0000117781,0.000008016968,0.00002160964,0.00005107068,0.00001677843],"domain_scores_gemma":[0.9999557,0.00001346572,0.000007576333,0.000003058574,0.00001411196,0.000006166528],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006903535,0.0000841514,0.0001077358,0.009186149,0.00004954867,0.0001921493,0.00004754401,0.0005580002,0.02704474,0.01668744,0.03334476,0.9126288],"study_design_scores_gemma":[0.000005278742,0.00003310541,0.0001442042,0.000296116,0.00001490618,0.0003197283,0.00000797245,0.00008557494,0.003556397,0.001089358,0.9944407,0.000006675119],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0008904504,0.9878358,0.001032873,0.0003537373,0.0005302377,0.00001526169,0.00007446697,0.00004760643,0.009219508],"genre_scores_gemma":[0.004077348,0.9882626,0.0005954786,0.0002156944,0.0002135606,0.00001915321,0.0001026703,0.000005409654,0.006508024],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003923822,"threshold_uncertainty_score":0.01312655,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04346767454886808,"score_gpt":0.2909121439826024,"score_spread":0.2474444694337343,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}