{"id":"W2920935501","doi":"10.1038/s41598-019-40764-7","title":"Profibrotic epithelial phenotype: a central role for MRTF and TAZ","year":2019,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Hippo pathway signaling and YAP/TAZ","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; St. Michael's Hospital","funders":"Canadian Institutes of Health Research; Kidney Foundation of Canada; Natural Sciences and Engineering Research Council of Canada; Government of Canada","keywords":"CTGF; RHOA; Myofibroblast; Cell biology; Gene silencing; Transforming growth factor; Growth factor; Cancer research; Hedgehog signaling pathway; Transcription factor; Transdifferentiation; Biology; Fibrosis; GLI1; Transforming growth factor beta; Epithelial–mesenchymal transition; Chemistry; Signal transduction; Downregulation and upregulation; Pathology; Stem cell; Medicine; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001942065,0.0003853005,0.0003553509,0.0003222346,0.000219788,0.0003679158,0.0001905881,0.0003485309,0.0009608521],"category_scores_gemma":[0.0001038148,0.0001205565,0.0003397679,0.0001483531,0.0003574183,0.0003527721,0.0002553281,0.0004640569,0.0002591261],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000193133,"about_ca_system_score_gemma":0.0001929852,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002768491,"about_ca_topic_score_gemma":0.0002943352,"domain_scores_codex":[0.9998168,0.00002404379,0.00001408612,0.0000433024,0.00004380829,0.00005788791],"domain_scores_gemma":[0.9998291,0.00001107096,0.00007099605,0.00001504738,0.0000230003,0.00005077964],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000157949,0.00001266606,0.0003318917,0.00006494694,0.000006172074,0.00007709221,0.00002186789,0.00002056725,0.9972975,0.0002406777,0.00001825904,0.001750416],"study_design_scores_gemma":[0.00005698706,0.0007684787,0.04516833,0.00003058628,0.0000569607,0.001611925,0.0001983751,0.0009158742,0.9439048,0.0002724935,0.007001818,0.00001349862],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9654734,0.01702379,0.01283254,0.0007350451,0.00005192417,0.00004823618,0.0004024194,0.0002310977,0.003201618],"genre_scores_gemma":[0.991565,0.002733118,0.002809827,0.0001079913,0.00004057094,0.00004285444,0.000245743,0.00001803106,0.002436898],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009608521,"threshold_uncertainty_score":0.003214359,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005735844270974777,"score_gpt":0.2172413918264728,"score_spread":0.211505547555498,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}