{"id":"W2920935501","doi":"10.1038/s41598-019-40764-7","title":"Profibrotic epithelial phenotype: a central role for MRTF and TAZ","year":2019,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Hippo pathway signaling and YAP/TAZ","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; St. Michael's Hospital","funders":"Canadian Institutes of Health Research; Kidney Foundation of Canada; Natural Sciences and Engineering Research Council of Canada; Government of Canada","keywords":"CTGF; RHOA; Myofibroblast; Cell biology; Gene silencing; Transforming growth factor; Growth factor; Cancer research; Hedgehog signaling pathway; Transcription factor; Transdifferentiation; Biology; Fibrosis; GLI1; Transforming growth factor beta; Epithelial–mesenchymal transition; Chemistry; Signal transduction; Downregulation and upregulation; Pathology; Stem cell; Medicine; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005110028,0.0001195005,0.0001270476,0.00003784028,0.0001433381,0.0001107162,0.00006734741,0.00009901947,0.00003478894],"category_scores_gemma":[0.00008639805,0.0001054474,0.00008054774,0.0000748297,0.0001021543,0.000005307056,0.00005808087,0.00004488569,0.00001918103],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008049076,"about_ca_system_score_gemma":0.0001499254,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000915584,"about_ca_topic_score_gemma":0.00000681889,"domain_scores_codex":[0.9985965,0.00002263325,0.0002240048,0.0006563526,0.0001591444,0.0003413722],"domain_scores_gemma":[0.9991852,0.000007194292,0.0001132299,0.0004843643,0.00009437932,0.0001156149],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000314719,0.00002739137,0.00361496,0.00003508159,0.00001465663,0.000009057385,0.0001027413,0.00003566636,0.9941757,0.00003824983,0.0004753252,0.001439707],"study_design_scores_gemma":[0.0003501508,0.0002043011,0.0009093104,0.00002567252,0.00002080277,0.0001110952,0.00007918708,0.0002986772,0.8065487,0.00176341,0.1894489,0.0002398524],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952516,0.0004658476,0.0003092765,0.00004102301,0.002602038,0.0005228842,0.00001457063,0.00001854598,0.0007742248],"genre_scores_gemma":[0.9900216,0.000003608022,0.0007246102,0.00003466786,0.0002061688,0.00002781015,0.000163878,0.0000184232,0.008799236],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1889736,"threshold_uncertainty_score":0.4300022,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005735844270974777,"score_gpt":0.2172413918264728,"score_spread":0.211505547555498,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}