{"id":"W2920961247","doi":"10.1016/j.celrep.2019.02.051","title":"Interphase Microtubules Safeguard Mitotic Progression by Suppressing an Aurora B-Dependent Arrest Induced by DNA Replication Stress","year":2019,"lang":"en","type":"article","venue":"Cell Reports","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Université de Montréal; McGill University; Institute for Research in Immunology and Cancer","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Canada Research Chairs","keywords":"Cell biology; G2-M DNA damage checkpoint; Mitosis; Mitotic exit; DNA damage; Kinetochore; Biology; Spindle checkpoint; Cell cycle checkpoint; Interphase; Microtubule; DNA replication; CHEK1; Spindle apparatus; Cell cycle; Genetics; DNA; Cell division; Cell; Chromosome; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005081326,0.0003214062,0.0001277452,0.0001533473,0.0001221587,0.000249638,0.000128966,0.0001511885,0.001316796],"category_scores_gemma":[0.00008157478,0.00011525,0.0001080927,0.00005930138,0.0001141323,0.0001121528,0.0001682,0.0003202375,0.0003190414],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000154778,"about_ca_system_score_gemma":0.0001411787,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005772559,"about_ca_topic_score_gemma":0.001142055,"domain_scores_codex":[0.9999502,0.000007438282,0.000004500137,0.00001051301,0.00001120474,0.00001619065],"domain_scores_gemma":[0.999871,0.00001155233,0.00004113014,0.00001664152,0.00001358555,0.00004607828],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004852736,0.000005412779,0.00005824861,0.00000809876,0.000001573875,0.00001120881,0.000002486972,0.0000121616,0.9994082,0.00003554721,0.00001332144,0.0003952234],"study_design_scores_gemma":[0.000009068331,0.0001413052,0.003026122,0.000005399663,0.000009002593,0.00007725906,0.00001383357,0.0004072816,0.9945136,0.00003735199,0.001757992,0.000001854991],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954513,0.001032546,0.001761544,0.00007429819,0.00002220241,0.00001229265,0.0001742249,0.0001033322,0.001368182],"genre_scores_gemma":[0.9961199,0.0004085127,0.0007066205,0.00002533564,0.000007561399,0.000009389525,0.0001992367,0.00002385531,0.002499672],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001316796,"threshold_uncertainty_score":0.004405081,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006332462284741723,"score_gpt":0.2562046234422533,"score_spread":0.2498721611575116,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}