{"id":"W2920968324","doi":"10.1002/cam4.2042","title":"Persistent janus kinase‐signaling in chronic lymphocytic leukemia patients on ibrutinib: Results of a phase I trial","year":2019,"lang":"en","type":"article","venue":"Cancer Medicine","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Hospital; University of Toronto; Sunnybrook Health Science Centre","funders":"Canadian Institutes of Health Research; Leukemia and Lymphoma Society of Canada; European Hematology Association; Institute of Cancer Research; Leukemia and Lymphoma Society","keywords":"Ibrutinib; Ruxolitinib; Medicine; Chronic lymphocytic leukemia; Janus kinase; Internal medicine; Tyrosine kinase 2; Bruton's tyrosine kinase; Oncology; Leukemia; Pharmacology; Immunology; Cytokine; Myelofibrosis; Bone marrow; Tyrosine kinase; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002267389,0.0008777167,0.001289797,0.0002211731,0.0003370421,0.0008400709,0.0004621298,0.0009448563,0.002024357],"category_scores_gemma":[0.0008827657,0.0002910802,0.00123431,0.0003058538,0.0006622447,0.0006499432,0.0002324447,0.00194245,0.0003659832],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000772702,"about_ca_system_score_gemma":0.001031452,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006651854,"about_ca_topic_score_gemma":0.001899678,"domain_scores_codex":[0.9994567,0.0002878211,0.00003907319,0.00006505833,0.00004267285,0.000108644],"domain_scores_gemma":[0.9993143,0.0001543537,0.0001272413,0.0000586583,0.00004935315,0.0002961333],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7513192,0.03180968,0.01251425,0.0008156273,0.001952125,0.0001843317,0.0002669672,0.001387807,0.02543796,0.0002841264,0.003777324,0.1702505],"study_design_scores_gemma":[0.67293,0.3038883,0.01439929,0.00009272555,0.0009453201,0.0002154674,0.00007743676,0.0008754532,0.002553575,0.00021948,0.003775787,0.00002716311],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.989111,0.00613525,0.0003695285,0.0008541322,0.0001294179,0.001074404,0.0006149972,0.00004255857,0.001668606],"genre_scores_gemma":[0.9914602,0.003006984,0.000879774,0.0008221495,0.0002081386,0.001268604,0.001207661,0.00001456428,0.001131942],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002267389,"threshold_uncertainty_score":0.01199126,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04055665254502011,"score_gpt":0.3564501784535835,"score_spread":0.3158935259085634,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}