{"id":"W2920989146","doi":"10.1093/jcag/gwz006.015","title":"A16 SENSING OF A MICROBIAL METABOLITE BY FIBROBLASTS THROUGH THE PREGNANE X RECEPTOR RESTRAINS INFLAMMATION AND FIBROSIS IN MICE","year":2019,"lang":"en","type":"article","venue":"Journal of the Canadian Association of Gastroenterology","topic":"Digestive system and related health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Pregnane X receptor; Inflammation; Fibrosis; Metabolite; Sirius Red; Biology; Receptor; Pharmacology; Immunology; Endocrinology; Nuclear receptor; Internal medicine; Medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005524168,0.00006985871,0.0002085686,0.0000576129,0.00003778994,0.000007538288,0.0001190744,0.0001481582,0.000003547194],"category_scores_gemma":[0.0001416386,0.0000476528,0.0000759324,0.00006406888,0.0000515615,0.000009829129,0.00002278947,0.0001460193,5.153985e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001337141,"about_ca_system_score_gemma":0.0002053265,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002507486,"about_ca_topic_score_gemma":0.05088886,"domain_scores_codex":[0.9988268,0.0003860158,0.0004251562,0.00007963688,0.0001047592,0.000177658],"domain_scores_gemma":[0.9986999,0.00003011089,0.0009556593,0.00009060946,0.0001761492,0.00004758997],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002231715,0.00001278314,0.188814,0.00004345183,0.0001475334,3.704106e-7,0.000540277,0.0002408848,0.8067782,0.00002521882,0.003079326,0.00009474295],"study_design_scores_gemma":[0.008386683,0.003528381,0.7232086,0.001222739,0.0002339233,0.0002396859,0.001024324,0.00008976315,0.2186881,0.0001824811,0.04291848,0.0002768298],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941888,0.0001250705,0.00001581183,0.00511482,0.0002513537,0.0001513079,0.00006012336,4.09623e-7,0.00009231615],"genre_scores_gemma":[0.9991993,0.0001046529,0.0001501706,0.0001909305,0.00006196387,3.350833e-7,0.000009751173,0.000006380072,0.0002764864],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5880901,"threshold_uncertainty_score":0.9664299,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003619193337856851,"score_gpt":0.2033464922057746,"score_spread":0.1997272988679177,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}