{"id":"W2920989146","doi":"10.1093/jcag/gwz006.015","title":"A16 SENSING OF A MICROBIAL METABOLITE BY FIBROBLASTS THROUGH THE PREGNANE X RECEPTOR RESTRAINS INFLAMMATION AND FIBROSIS IN MICE","year":2019,"lang":"en","type":"article","venue":"Journal of the Canadian Association of Gastroenterology","topic":"Digestive system and related health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Pregnane X receptor; Inflammation; Fibrosis; Metabolite; Sirius Red; Biology; Receptor; Pharmacology; Immunology; Endocrinology; Nuclear receptor; Internal medicine; Medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006316752,0.000878347,0.0007560292,0.00154841,0.0004624803,0.0008681852,0.0005763085,0.001396661,0.005004877],"category_scores_gemma":[0.0002711179,0.0008664312,0.001499753,0.0005191735,0.000850498,0.0006854999,0.0004810684,0.00347024,0.002223113],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004232787,"about_ca_system_score_gemma":0.0004469879,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001002481,"about_ca_topic_score_gemma":0.001652418,"domain_scores_codex":[0.9989256,0.0001508653,0.000134389,0.0002942261,0.0002650133,0.0002298303],"domain_scores_gemma":[0.9992519,0.00007969206,0.0002114916,0.0001246905,0.00004882333,0.0002834651],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008117385,0.0003231892,0.0003272028,0.00007629247,0.00001842459,0.0001632938,0.00008050165,0.00009953186,0.9963426,0.0002929223,0.0001833523,0.001281059],"study_design_scores_gemma":[0.0005200292,0.004847644,0.01031828,0.0001121578,0.0001209537,0.001378937,0.0003597387,0.002540592,0.967605,0.0005949223,0.01154999,0.00005168025],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9747205,0.003536629,0.007491251,0.001042644,0.0003607833,0.0002460281,0.005252588,0.0007235631,0.006626057],"genre_scores_gemma":[0.9439375,0.003989467,0.01125771,0.0007094534,0.000118204,0.0007991957,0.004162823,0.0003302299,0.03469547],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005004877,"threshold_uncertainty_score":0.016743,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003619193337856851,"score_gpt":0.2033464922057746,"score_spread":0.1997272988679177,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}