{"id":"W2921008740","doi":"10.1016/s1474-4422(19)30026-2","title":"Safety and efficacy of sonothrombolysis for acute ischaemic stroke: a multicentre, double-blind, phase 3, randomised controlled trial","year":2019,"lang":"en","type":"article","venue":"The Lancet Neurology","topic":"Ultrasound and Hyperthermia Applications","field":"Engineering","cited_by":84,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta; University of Calgary","funders":"Daiichi Sankyo Europe; Seventh Framework Programme; Bayer Fund; Shire; Bristol-Myers Squibb; CSL Behring; Bundesministerium für Bildung und Forschung; Biogen; Welch Foundation; Novartis; Merck; Pfizer; National Institutes of Health; Medtronic; Boehringer Ingelheim","keywords":"Medicine; Thrombolysis; Modified Rankin Scale; Randomized controlled trial; Transcranial Doppler; Interim analysis; Odds ratio; Population; Fibrinolytic agent; Stroke (engine); Ultrasound; Tissue plasminogen activator; Physical therapy; Internal medicine; Ischemia; Ischemic stroke; Radiology; Myocardial infarction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001891499,0.000127336,0.0007192336,0.00003845525,0.00004948611,0.00001074276,0.0001797166,0.00008223293,0.00005110373],"category_scores_gemma":[0.00002768652,0.00008672714,0.0001290652,0.00005918059,0.00005862773,0.00003176137,0.00001653134,0.0001500034,0.00001218126],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004006498,"about_ca_system_score_gemma":0.00001132337,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003570385,"about_ca_topic_score_gemma":0.000005657982,"domain_scores_codex":[0.999221,0.00004878356,0.0002852543,0.0001587522,0.00005595858,0.0002302131],"domain_scores_gemma":[0.9984121,0.001136774,0.00008095746,0.0003125593,0.00002358076,0.00003399015],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9472522,0.0000986658,0.00002831944,0.00001502985,0.0005341296,3.427848e-7,0.0002270527,0.001276252,0.04916498,0.0004111027,0.00009880765,0.0008931468],"study_design_scores_gemma":[0.9765477,0.0002806322,0.00005783999,0.000001633997,0.0004320878,0.000005098176,0.000007752153,0.01738779,0.001067842,0.00004125831,0.00408613,0.00008423183],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919871,0.0001445526,0.001648721,0.0009102187,0.0002327261,0.004405912,0.0000675292,0.00007806201,0.000525146],"genre_scores_gemma":[0.9985889,0.0003521404,0.00009056865,0.0002242591,0.0002495129,0.0003544853,0.00001929098,0.00002380796,0.00009702447],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04809713,"threshold_uncertainty_score":0.353663,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02104800054649133,"score_gpt":0.2918371316747005,"score_spread":0.2707891311282092,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}