{"id":"W2921063124","doi":"10.1111/bjh.15865","title":"Expression and function of phosphoinositide 3‐kinase delta in mesenchymal stromal cells from normal and leukaemic bone marrow","year":2019,"lang":"en","type":"article","venue":"British Journal of Haematology","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; Health Sciences Centre; University of Manitoba; Research Institute in Oncology and Hematology; CancerCare Manitoba","funders":"Leukemia and Lymphoma Society of Canada; CancerCare Manitoba Foundation; Research Manitoba","keywords":"Idelalisib; Mesenchymal stem cell; Bone marrow; Stromal cell; PI3K/AKT/mTOR pathway; Haematopoiesis; Cancer research; Chronic lymphocytic leukemia; Phosphoinositide 3-kinase; Medicine; Biology; Immunology; Pathology; Leukemia; Stem cell; Cell biology; Signal transduction; Ibrutinib","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003914291,0.0001218133,0.0007452882,0.000192676,0.00002762853,0.00001900199,0.00008284782,0.0001811854,0.0002520057],"category_scores_gemma":[0.0001241182,0.0001256706,0.0000691634,0.0001014336,0.0001787511,0.0002048399,0.0001168766,0.0004331213,0.000005280304],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004595348,"about_ca_system_score_gemma":0.0009517384,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001590135,"about_ca_topic_score_gemma":0.0001864036,"domain_scores_codex":[0.9983649,0.0001273448,0.0006534068,0.000217771,0.0003416126,0.0002950047],"domain_scores_gemma":[0.9989948,0.0002454285,0.0002947747,0.0001427374,0.0001402452,0.0001820375],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"case_report","study_design_scores_codex":[0.006104467,0.0004022673,0.09013078,0.0009479202,0.0001734482,0.07820905,0.0004157879,0.00004286296,0.802435,0.00008897213,0.003236158,0.01781322],"study_design_scores_gemma":[0.06639767,0.002497448,0.107829,0.00488864,0.000240372,0.4403512,0.001154132,0.002968579,0.3723516,0.0005435081,0.0004069755,0.0003708937],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9893028,0.009996977,0.00006176146,0.00008513911,0.0001903532,0.0001980903,0.00001796946,0.000004933273,0.0001419765],"genre_scores_gemma":[0.9978918,0.0009643232,0.0009298087,0.00006069701,0.00006091277,0.00000203092,0.000009544369,0.00001725229,0.00006366849],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4300835,"threshold_uncertainty_score":0.51247,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007748141663317778,"score_gpt":0.2396104386933656,"score_spread":0.2318622970300478,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}