{"id":"W2921063124","doi":"10.1111/bjh.15865","title":"Expression and function of phosphoinositide 3‐kinase delta in mesenchymal stromal cells from normal and leukaemic bone marrow","year":2019,"lang":"en","type":"article","venue":"British Journal of Haematology","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; Health Sciences Centre; University of Manitoba; Research Institute in Oncology and Hematology; CancerCare Manitoba","funders":"Leukemia and Lymphoma Society of Canada; CancerCare Manitoba Foundation; Research Manitoba","keywords":"Idelalisib; Mesenchymal stem cell; Bone marrow; Stromal cell; PI3K/AKT/mTOR pathway; Haematopoiesis; Cancer research; Chronic lymphocytic leukemia; Phosphoinositide 3-kinase; Medicine; Biology; Immunology; Pathology; Leukemia; Stem cell; Cell biology; Signal transduction; Ibrutinib","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001225781,0.0001191068,0.0001424016,0.0004007155,0.0001692148,0.0003484257,0.0001171353,0.0001642861,0.001528817],"category_scores_gemma":[0.000123827,0.0000931605,0.0001381097,0.0003175006,0.0001666224,0.0001111118,0.0001787629,0.0003159787,0.0004322712],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002110305,"about_ca_system_score_gemma":0.0001405745,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001081874,"about_ca_topic_score_gemma":0.0009122704,"domain_scores_codex":[0.9998478,0.00002178288,0.00002172506,0.00002088305,0.00004851386,0.00003938244],"domain_scores_gemma":[0.9999095,0.00002067639,0.0000140822,0.000007774305,0.00001572785,0.00003221239],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002152118,0.00002029771,0.001067762,0.00003316673,0.000004710952,0.00009059263,0.00007207233,0.00002823599,0.9964973,0.0002012465,0.00002746523,0.001741923],"study_design_scores_gemma":[0.00008451204,0.0007677239,0.1032339,0.0000324166,0.00007129819,0.001842547,0.0005688265,0.001467076,0.8802357,0.0002734197,0.01140687,0.00001585177],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944167,0.002326352,0.0008164447,0.00005011292,0.00001003265,0.00002484704,0.0006560289,0.00001644643,0.001683076],"genre_scores_gemma":[0.9943416,0.001263353,0.0008852281,0.00004504761,0.000009345815,0.00004522896,0.00149687,0.000007383326,0.001905913],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001528817,"threshold_uncertainty_score":0.005114436,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007748141663317778,"score_gpt":0.2396104386933656,"score_spread":0.2318622970300478,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}