{"id":"W2921068994","doi":"10.1182/bloodadvances.2018025593","title":"Oncolytic immunotherapy and bortezomib synergy improves survival of refractory multiple myeloma in a preclinical model","year":2019,"lang":"en","type":"article","venue":"Blood Advances","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Children's Hospital; Alberta Health Services; Calgary Laboratory Services; Oncolytics Biotech (Canada); University of Calgary","funders":"National Cancer Institute; Oncolytics Biotech; Alberta Innovates; Cancer Research Society","keywords":"Oncolytic virus; Bortezomib; Cancer research; Medicine; Multiple myeloma; Tumor microenvironment; Immune system; Immunotherapy; Immunosuppression; Immunology; Pharmacology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003196204,0.0001466556,0.000269347,0.0000555577,0.00002144293,0.000009368947,0.0002079297,0.0001282451,0.00001017873],"category_scores_gemma":[0.0000863825,0.0001336791,0.00006723231,0.00007804503,0.0001174828,0.00001265355,0.00007945926,0.0001227624,0.000002226411],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000081635,"about_ca_system_score_gemma":0.0001401489,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001739527,"about_ca_topic_score_gemma":0.0003945944,"domain_scores_codex":[0.998803,0.00009490192,0.0003025701,0.00038445,0.0001659007,0.0002491718],"domain_scores_gemma":[0.9993078,0.00008810041,0.000105515,0.0003883365,0.00005460401,0.0000556476],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002584059,0.0002656952,0.0166821,0.0000387626,0.00006240144,0.000001417122,0.00003946217,0.0005058175,0.9594219,0.00001310459,0.000003797546,0.02038145],"study_design_scores_gemma":[0.006571786,0.006658593,0.01415425,0.00005709003,0.00001472689,0.000003842268,0.0001258869,0.004146884,0.9640626,0.0002655649,0.003565137,0.000373609],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9873403,0.0118755,0.00004196851,0.00003226708,0.00006641947,0.0002746027,0.00001715084,0.000007394453,0.0003444277],"genre_scores_gemma":[0.9941176,0.00461343,0.0005830727,0.0000639833,0.00005523745,0.00002952248,0.00001625403,0.00002705709,0.0004938248],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02000784,"threshold_uncertainty_score":0.5451274,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01746604095415512,"score_gpt":0.3217153832903964,"score_spread":0.3042493423362413,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}