{"id":"W2921068994","doi":"10.1182/bloodadvances.2018025593","title":"Oncolytic immunotherapy and bortezomib synergy improves survival of refractory multiple myeloma in a preclinical model","year":2019,"lang":"en","type":"article","venue":"Blood Advances","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Children's Hospital; Alberta Health Services; Calgary Laboratory Services; Oncolytics Biotech (Canada); University of Calgary","funders":"National Cancer Institute; Oncolytics Biotech; Alberta Innovates; Cancer Research Society","keywords":"Oncolytic virus; Bortezomib; Cancer research; Medicine; Multiple myeloma; Tumor microenvironment; Immune system; Immunotherapy; Immunosuppression; Immunology; Pharmacology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003461689,0.0009010513,0.0007450325,0.0005236577,0.0002923125,0.0003809861,0.0005078681,0.0004872759,0.001661361],"category_scores_gemma":[0.0001101069,0.0002132406,0.0004263188,0.0002192636,0.0003298394,0.0004032153,0.0001862844,0.001661384,0.0004302277],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004322823,"about_ca_system_score_gemma":0.0004442864,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001002883,"about_ca_topic_score_gemma":0.001487219,"domain_scores_codex":[0.999803,0.00003749246,0.00001387527,0.00003895396,0.00004585409,0.00006086544],"domain_scores_gemma":[0.9998698,0.0000172549,0.00003390517,0.00001953918,0.00001059514,0.00004888881],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001339771,0.001688966,0.000172273,0.00005902749,0.00002408255,0.00005820192,0.00003316012,0.0004799242,0.9912066,0.0002597408,0.0002991435,0.004379053],"study_design_scores_gemma":[0.0003707065,0.01554388,0.001568556,0.00001529219,0.00007127385,0.0001855204,0.000029038,0.002545413,0.9765657,0.000137843,0.002957667,0.000009219744],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928157,0.001512864,0.002367828,0.0003027277,0.0001459802,0.00009891109,0.0005115757,0.0002348544,0.002009497],"genre_scores_gemma":[0.992904,0.0009836218,0.001843156,0.00006644588,0.00004876612,0.0001188895,0.0006085578,0.00003322147,0.003393314],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001661361,"threshold_uncertainty_score":0.005557775,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01746604095415512,"score_gpt":0.3217153832903964,"score_spread":0.3042493423362413,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}