{"id":"W2921074918","doi":"10.1038/s41598-018-38385-7","title":"Pre-surgical neoadjuvant oncolytic virotherapy confers protection against rechallenge in a murine model of breast cancer","year":2019,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; McMaster University; Centre Hospitalier de l’Université de Montréal; Ottawa Hospital; University of Ottawa","funders":"Stichting voor de Technische Wetenschappen; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Cancer Research Society; Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; Terry Fox Foundation","keywords":"Oncolytic virus; Vesicular stomatitis virus; Medicine; Breast cancer; Virotherapy; Herpes simplex virus; Virus; Immune system; Cancer; Cancer research; Oncology; Immunology; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001150901,0.000145295,0.0002132921,0.0001453725,0.00005086641,0.0000334957,0.0001505097,0.0001257374,0.0001193863],"category_scores_gemma":[0.00001450634,0.0001310326,0.00009921203,0.0002406076,0.0001590698,0.000009141691,0.00006775386,0.0001392401,0.000005316591],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007505407,"about_ca_system_score_gemma":0.0004585674,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006189627,"about_ca_topic_score_gemma":0.0004592577,"domain_scores_codex":[0.9980597,0.00008729196,0.0004152861,0.0007159117,0.0004130932,0.000308749],"domain_scores_gemma":[0.9987947,0.000004278349,0.0001903828,0.0007682191,0.0001545528,0.00008785483],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001169761,0.0001523991,0.001207822,0.00004037002,0.00002419048,0.00002906835,0.00009887497,0.01953128,0.9655409,0.000002337991,0.00007632238,0.0121266],"study_design_scores_gemma":[0.001351474,0.0006865743,0.0008823851,0.00011476,0.000005282678,0.0001027291,0.00004003784,0.01929749,0.9748211,0.0002163653,0.002202458,0.0002793266],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972253,0.0004128185,0.00008460612,0.0001716341,0.0005624799,0.00100258,0.00001593435,0.00001150189,0.0005131451],"genre_scores_gemma":[0.9971682,0.0002280384,0.00005449952,0.0000207003,0.00005453272,0.0001343361,0.0000274885,0.00002536372,0.002286827],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01184727,"threshold_uncertainty_score":0.5343354,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02518850737594629,"score_gpt":0.3066493017599135,"score_spread":0.2814607943839672,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}