{"id":"W2921106016","doi":"10.1007/s00401-019-01987-0","title":"cIMPACT-NOW update 4: diffuse gliomas characterized by MYB, MYBL1, or FGFR1 alterations or BRAFV600E mutation","year":2019,"lang":"en","type":"letter","venue":"Acta Neuropathologica","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":252,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"Mutation; Cancer research; MYB; Glioma; Medicine; Pathology; Biology; Genetics; Gene; Transcription factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0001802285,0.001011702,0.001444005,0.0004610109,0.0002548714,0.0003034779,0.0004135901,0.0009403988,0.002577154],"category_scores_gemma":[0.0004860576,0.0006072889,0.0004330534,0.000527007,0.0001441014,0.0002952193,0.0001817213,0.001542345,0.00182411],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000158917,"about_ca_system_score_gemma":0.0002105368,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007691488,"about_ca_topic_score_gemma":0.00000333772,"domain_scores_codex":[0.9955435,0.0005432957,0.0008773733,0.001391356,0.0007138747,0.0009306333],"domain_scores_gemma":[0.9967808,0.000677003,0.0007092672,0.001408305,0.0001985332,0.00022607],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0007629965,0.001121746,0.0003372475,0.0002159925,0.0001730166,0.06124301,0.00007705137,4.202011e-7,0.05040534,0.000001685309,0.8841756,0.001485873],"study_design_scores_gemma":[0.006133801,0.002783276,0.006522941,0.0002097866,0.0009229819,0.005332006,0.00001018808,0.00003731442,0.003862132,0.00001077978,0.9734169,0.0007578838],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.4174003,0.0002839438,0.00003365387,0.5739183,0.001416042,0.003863804,0.001575926,0.0005684405,0.0009395191],"genre_scores_gemma":[0.2470705,0.001797193,0.000348764,0.7206711,0.002692705,0.001022443,0.01183274,0.0003162061,0.01424836],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.1703298,"threshold_uncertainty_score":0.9996378,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02948175259798109,"score_gpt":0.2785274313116085,"score_spread":0.2490456787136274,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}