{"id":"W2921135690","doi":"10.1002/em.22277","title":"The development and prevalidation of an<i>in vitro</i>mutagenicity assay based on MutaMouse primary hepatocytes, Part II: Assay performance for the identification of mutagenic chemicals","year":2019,"lang":"en","type":"article","venue":"Environmental and Molecular Mutagenesis","topic":"Carcinogens and Genotoxicity Assessment","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Health Canada","funders":"Natural Sciences and Engineering Research Council of Canada; Health Canada","keywords":"In vitro; Mutagen; Identification (biology); Biology; In vitro toxicology; Primary (astronomy); Chemistry; Molecular biology; Toxicology; Genetics; Carcinogen; Botany","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001817813,0.001088843,0.0007178112,0.0007900237,0.0003617516,0.0007511281,0.0005934425,0.0007889257,0.001312892],"category_scores_gemma":[0.001521425,0.0004886984,0.0004985742,0.0004970742,0.0004192001,0.0003366479,0.0006495899,0.0008251081,0.0008101639],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004059451,"about_ca_system_score_gemma":0.0005215987,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001242734,"about_ca_topic_score_gemma":0.003020796,"domain_scores_codex":[0.9978024,0.0006733685,0.0003412221,0.0003417491,0.000748072,0.00009308969],"domain_scores_gemma":[0.9985305,0.0004015314,0.0003047212,0.0002699899,0.0004204988,0.00007270263],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004480749,0.00003449653,0.0006005905,0.00003778894,0.000005959229,0.0000185827,0.00001318727,0.0001220622,0.9980247,0.00002587303,0.00002567019,0.001046279],"study_design_scores_gemma":[0.000002629519,0.0003803581,0.001902439,0.000002741557,0.00001299876,0.00007300587,0.00001030836,0.0003267415,0.9969124,0.000008460598,0.0003628229,0.000005119055],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8257347,0.001399918,0.1628233,0.0002107224,0.00009278168,0.001578924,0.003293679,0.0008230018,0.004042825],"genre_scores_gemma":[0.8048545,0.002754797,0.1747263,0.000297156,0.00005125195,0.001749877,0.007553372,0.0002827977,0.007729977],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001817813,"threshold_uncertainty_score":0.009613574,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00543425861597345,"score_gpt":0.2061848947279497,"score_spread":0.2007506361119763,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}