{"id":"W2921157433","doi":"10.1101/581934","title":"Plasticity at the DNA recognition site of the MeCP2 mCG-binding domain","year":2019,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"National Institute of General Medical Sciences; Western Economic Diversification Canada; Canadian Institutes of Health Research; Office of Science; Huazhong Agricultural University; Novartis Pharma; Ontario Genomics Institute; National Cancer Institute; National Research Council Canada; European Federation of Pharmaceutical Industries and Associations; Merck KGaA; National Institutes of Health; Ontario Ministry of Research, Innovation and Science; Ontario Genomics; Fundação de Amparo à Pesquisa do Estado de São Paulo; Genome Canada; Pfizer; University of Saskatchewan; Natural Sciences and Engineering Research Council of Canada; Canadian Light Source; Argonne National Laboratory; U.S. Department of Energy; Howard Hughes Medical Institute","keywords":"MECP2; DNA; Scaffold/matrix attachment region; Promoter; Biology; Molecular biology; DNA-binding domain; Activator (genetics); Binding site; Transcription (linguistics); Transcription factor; Cell biology; Chemistry; Gene; Genetics; Histone; Gene expression; Phenotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009516384,0.0001892098,0.0001817727,0.0001000845,0.0001610156,0.000209001,0.0002921637,0.0002217561,0.002052048],"category_scores_gemma":[0.0001960097,0.0001090172,0.0001709481,0.00008068977,0.0001990392,0.000141961,0.0002210355,0.0003738997,0.0006091258],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002853859,"about_ca_system_score_gemma":0.0001633475,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001055639,"about_ca_topic_score_gemma":0.001194849,"domain_scores_codex":[0.9999294,0.000009301075,0.000003901486,0.00002109196,0.00002117287,0.00001497489],"domain_scores_gemma":[0.9999131,0.00002008994,0.00001593509,0.00000941634,0.00001197101,0.00002948274],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001472783,0.00001260956,0.001284571,0.00004331927,0.00001174065,0.0003478012,0.00002491401,0.0005149064,0.9952433,0.0004529198,0.0001859345,0.001730788],"study_design_scores_gemma":[0.00007931851,0.0002557075,0.03747981,0.00002878518,0.00005244619,0.002194927,0.0001201434,0.01579719,0.932971,0.0008003314,0.0101782,0.00004214849],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934482,0.0006010453,0.003801827,0.00009876496,0.00002741888,0.00001415634,0.0001748438,0.0001071545,0.001726582],"genre_scores_gemma":[0.9980918,0.00005100933,0.0009905809,0.000047915,0.000004357435,0.00000707901,0.0001352208,0.000009962823,0.0006619607],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002052048,"threshold_uncertainty_score":0.006864727,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01071333564641346,"score_gpt":0.1968497535590742,"score_spread":0.1861364179126608,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}