{"id":"W2921175534","doi":"10.1016/j.isci.2019.03.011","title":"Biased Signaling of the Mu Opioid Receptor Revealed in Native Neurons","year":2019,"lang":"en","type":"article","venue":"iScience","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":87,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Douglas Mental Health University Institute; Douglas College; Institute for Research in Immunology and Cancer; McGill University","funders":"European Regional Development Fund; Canadian Institutes of Health Research; National Institute on Drug Abuse; Agence Nationale de la Recherche; Canada Research Chairs; National Institutes of Health; Canada Foundation for Innovation","keywords":"Receptor; Drug discovery; Opioid; Pharmacology; Opioid receptor; Computational biology; Signal transduction; Drug; Neuroscience; Chemistry; Cell biology; Biology; Bioinformatics; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001191413,0.0002467922,0.0002600225,0.0001545899,0.00009282849,0.000376016,0.00016035,0.0001865103,0.0005559903],"category_scores_gemma":[0.0001455566,0.00009964827,0.0001555487,0.0001140993,0.0001892607,0.0002262149,0.0001992006,0.0004197933,0.0002572948],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002337459,"about_ca_system_score_gemma":0.0001474929,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003751676,"about_ca_topic_score_gemma":0.0006535016,"domain_scores_codex":[0.9998709,0.00001363063,0.000009403218,0.00003470871,0.00004544227,0.00002593387],"domain_scores_gemma":[0.999943,0.00001344191,0.00001670591,0.000008562158,0.000009836026,0.000008451517],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001477487,0.000003062828,0.0001039499,0.00001249212,0.000002070591,0.00001431456,0.000005770367,0.0000199961,0.9993334,0.00005143543,0.000005940964,0.0004327295],"study_design_scores_gemma":[0.00000232699,0.000107166,0.004103458,0.00000520933,0.00001174707,0.0001774484,0.00003470815,0.0005859018,0.9941737,0.00009735359,0.0006974588,0.000003485186],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9880185,0.001591133,0.008789113,0.00006564783,0.00001413436,0.00001366938,0.0003799537,0.00006664889,0.001061159],"genre_scores_gemma":[0.9903565,0.001761874,0.005692163,0.00009112537,0.000006308348,0.00003479208,0.000477171,0.00002574418,0.001554407],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005559903,"threshold_uncertainty_score":0.001859963,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01080771900932275,"score_gpt":0.236972620352265,"score_spread":0.2261649013429423,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}