{"id":"W2921213784","doi":"10.3390/cancers11030375","title":"The Effects of Pertuzumab and Its Combination with Trastuzumab on HER2 Homodimerization and Phosphorylation","year":2019,"lang":"en","type":"article","venue":"Cancers","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Cure Brain Cancer Foundation; Canadian Institutes of Health Research; Women and Children's Health Research Institute","keywords":"Pertuzumab; Trastuzumab; Phosphorylation; Chemistry; Chinese hamster ovary cell; Apoptosis; Molecular biology; Cancer research; Biochemistry; Biology; Receptor; Cancer; Breast cancer; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001831808,0.0003506523,0.000494906,0.0003429964,0.0001640298,0.0002737068,0.0001592986,0.0002428311,0.0008821482],"category_scores_gemma":[0.0002276692,0.0001394131,0.0004492244,0.0003678884,0.000146583,0.0003102039,0.0001645376,0.0004260919,0.0001761387],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001828177,"about_ca_system_score_gemma":0.0001883316,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000552658,"about_ca_topic_score_gemma":0.0007521141,"domain_scores_codex":[0.9997669,0.00004964482,0.00002543153,0.00003579474,0.00006435482,0.00005794146],"domain_scores_gemma":[0.9999011,0.0000263038,0.0000193329,0.000009271196,0.00001738444,0.0000266607],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002446437,0.000636303,0.001111883,0.0002579835,0.00008078324,0.0001759506,0.00006901656,0.0005305939,0.9783056,0.00007163254,0.0002835684,0.01603018],"study_design_scores_gemma":[0.0001622111,0.00580758,0.01847746,0.00001354023,0.0001755381,0.0005779045,0.0000965301,0.002394089,0.9676515,0.00006470744,0.004557755,0.00002110219],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9916193,0.006518798,0.0003170035,0.0001237046,0.00007702231,0.00002664139,0.0001169869,0.00002031524,0.001180042],"genre_scores_gemma":[0.9940163,0.003411517,0.0006864817,0.00007915862,0.00004410377,0.00004183238,0.0002231761,0.000006535241,0.001490906],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008821482,"threshold_uncertainty_score":0.002951086,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00902042721348332,"score_gpt":0.2752201647484832,"score_spread":0.2661997375349999,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}