{"id":"W2921219745","doi":"10.1186/s12989-019-0289-1","title":"In utero exposure to ultrafine particles promotes placental stress-induced programming of renin-angiotensin system-related elements in the offspring results in altered blood pressure in adult mice","year":2019,"lang":"en","type":"article","venue":"Particle and Fibre Toxicology","topic":"Air Quality and Health Impacts","field":"Environmental Science","cited_by":59,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Consejo Nacional de Ciencia y Tecnología","keywords":"Offspring; Oxidative stress; Endocrinology; Internal medicine; In utero; Fetus; Blood pressure; Angiotensin II; Placenta; Inflammation; Renin–angiotensin system; Medicine; Andrology; Biology; Pregnancy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001958518,0.000451668,0.0003565797,0.0006659066,0.0002318563,0.0003779976,0.0002961928,0.0004297077,0.001982883],"category_scores_gemma":[0.000126841,0.0004354958,0.0005050708,0.000212005,0.0004601824,0.0002476233,0.000263087,0.001263619,0.0003572932],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003231856,"about_ca_system_score_gemma":0.0002887991,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001458769,"about_ca_topic_score_gemma":0.002226182,"domain_scores_codex":[0.999712,0.0000336192,0.00002208785,0.0001066923,0.00006560961,0.00005992191],"domain_scores_gemma":[0.9997285,0.00002484902,0.00009867411,0.000029632,0.00002043919,0.0000978799],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008466068,0.0001725194,0.001391201,0.00003345666,0.00001544828,0.000124411,0.00006740008,0.00004682338,0.9957556,0.00007901721,0.0000694237,0.001398207],"study_design_scores_gemma":[0.00007529109,0.002564459,0.0641278,0.00002628177,0.0001162088,0.0005911315,0.0002437824,0.0008313286,0.9282185,0.0001857334,0.002997575,0.00002206279],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931572,0.001086873,0.002882033,0.0001937477,0.00004977252,0.00003789683,0.001556641,0.0001280342,0.0009078337],"genre_scores_gemma":[0.9842295,0.001680935,0.003032202,0.0001909507,0.00002373726,0.0001459791,0.001165345,0.00008009331,0.00945121],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001982883,"threshold_uncertainty_score":0.006633461,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0206440990858671,"score_gpt":0.2749872959065772,"score_spread":0.2543431968207101,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}