{"id":"W2921229297","doi":"10.1093/jcag/gwz006.040","title":"A41 ENDOPLASMIC RETICULUM STRESSED HUMAN COLON ORGANOIDS CONDITION DENDRITIC CELLS TO A PRO-INFLAMMATORY PHENOTYPE","year":2019,"lang":"en","type":"article","venue":"Journal of the Canadian Association of Gastroenterology","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"","keywords":"Endoplasmic reticulum; Unfolded protein response; Organoid; Cell biology; CD80; TLR5; CD86; Biology; Secretion; Inflammasome; Extracellular; Inflammation; Immune system; Signal transduction; CD40; Immunology; TLR2; T cell; Endocrinology; TLR4; Biochemistry; In vitro; Cytotoxic T cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001388883,0.0003418224,0.0003705379,0.0001807433,0.0001811737,0.0003519242,0.0001154426,0.0003293633,0.005132786],"category_scores_gemma":[0.00008978202,0.000135643,0.0003687877,0.0002102174,0.0001933553,0.0002572727,0.0002480489,0.001025413,0.001717367],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001938723,"about_ca_system_score_gemma":0.0001848001,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005077203,"about_ca_topic_score_gemma":0.0006093761,"domain_scores_codex":[0.9997111,0.00003686084,0.00003520662,0.00009455689,0.00006096348,0.00006132881],"domain_scores_gemma":[0.9998406,0.00002251945,0.00002149362,0.0000429823,0.00003212004,0.00004030962],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002742736,0.0000315308,0.0002077795,0.00005261962,0.000005187158,0.00007666067,0.00003660275,0.00003077179,0.9983175,0.00003564913,0.0001351548,0.0007962742],"study_design_scores_gemma":[0.00005671246,0.0009266717,0.007737213,0.00001559094,0.00003145103,0.0006085372,0.0001691369,0.000676683,0.9787567,0.00005681802,0.01095474,0.000009720696],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.98284,0.00294725,0.005095829,0.0003427565,0.0002996139,0.000135921,0.003359642,0.0001929699,0.004785981],"genre_scores_gemma":[0.9830547,0.001131823,0.003813351,0.000203422,0.00003859276,0.0001638109,0.00439593,0.0000383618,0.007160104],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005132786,"threshold_uncertainty_score":0.01717091,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00316284138466344,"score_gpt":0.2076919621332483,"score_spread":0.2045291207485849,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}