{"id":"W2921261426","doi":"10.3390/nu11030605","title":"Offspring of Mice Exposed to a Low-Protein Diet in Utero Demonstrate Changes in mTOR Signaling in Pancreatic Islets of Langerhans, Associated with Altered Glucagon and Insulin Expression and a Lower β-Cell Mass","year":2019,"lang":"en","type":"article","venue":"Nutrients","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; McMaster University; Lawson Health Research Institute","funders":"Canadian Institutes of Health Research; National Institutes of Health; Hort Innovation; Diabetes UK; Juvenile Diabetes Research Foundation United Kingdom","keywords":"Endocrinology; Internal medicine; Biology; Insulin; Offspring; PI3K/AKT/mTOR pathway; Islet; Glucagon; Pancreas; In utero; mTORC1; Signal transduction; Fetus; Medicine; Pregnancy; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001472882,0.0005070664,0.000327231,0.0006744215,0.000231363,0.000384756,0.0002002659,0.0004382759,0.003031306],"category_scores_gemma":[0.0001113868,0.0002583498,0.0003114847,0.0002075361,0.0004005265,0.0002568822,0.0002511003,0.001081272,0.0004758464],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002438693,"about_ca_system_score_gemma":0.0001839711,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005120985,"about_ca_topic_score_gemma":0.0009358141,"domain_scores_codex":[0.9998391,0.00001838584,0.00001422334,0.00006417021,0.00003091183,0.0000333358],"domain_scores_gemma":[0.9997455,0.0000319267,0.00009442327,0.00002432933,0.00001472976,0.00008907366],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004506859,0.00006208096,0.0008632781,0.00002330269,0.00001043981,0.0001128144,0.00003446927,0.00001899814,0.9973378,0.00006768581,0.00003756842,0.0009808856],"study_design_scores_gemma":[0.00005001711,0.001302019,0.04560162,0.00003021769,0.00008545555,0.001202736,0.0001964944,0.0003230948,0.9481097,0.0001605582,0.002922923,0.0000151471],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950404,0.0008793492,0.001946909,0.0001469053,0.00003853426,0.00001112817,0.0008755752,0.0000824263,0.0009788487],"genre_scores_gemma":[0.9830536,0.001632815,0.002914813,0.0001814635,0.0000250203,0.00009136181,0.001586202,0.0001119965,0.01040262],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003031306,"threshold_uncertainty_score":0.01014078,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01059229787108072,"score_gpt":0.214811048021727,"score_spread":0.2042187501506462,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}